Phenotypes associated with this allele

• Allele Symbol: Grin1^tm1Jjwd
• Allele Name: targeted mutation 1, John J Woodward
• Allele ID: MGI:5574216
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grin1^tm1Jjwd/Grin1^tm1Jjwd	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:5574228
ht2	Grin1^tm1Jjwd/Grin1^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:5574229

Genotype
MGI:5574228

hm1

• Allelic Composition: Grin1^tm1Jjwd/Grin1^tm1Jjwd
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:209690 )

• no mice are present at P21 despite normal Mendelian ratios at E18

nervous system

abnormal NMDA-mediated synaptic currents ( J:209690 )

• ethanol inhibition of NMDA current is impaired compared to in wild-type mice

• however, NMDA evoked currents are normal

Genotype
MGI:5574229

ht2

• Allelic Composition: Grin1^tm1Jjwd/Grin1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

behavior/neurological

decreased alcohol consumption ( J:209690 )

• during daily limited-access

increased alcohol consumption ( J:209690 )

• when given intermittent 24 hour access to ethanol

abnormal behavioral response to alcohol ( J:209690 )

• ethanol inhibition of NMDA current is intermediately impaired compared to in wild-type mice and homozygotes

• ethanol-treated mice fail to exhibit an increase in activity at low doses and exhibit less of a reduction in activity at high doses compared with wild-type mice

• ethanol-treated mice exhibit a faster recovery as tested by rotarod performance compared with wild-type mice

• ethanol-treated mice fail to exhibit an increase in time spent in the open arms of an elevated plus maze unlike wild-type mice

• however, ethanol-treated mice exhibit normal impairment of motor coordination, loss of righting reflex, hypothermia and ethanol metabolism

abnormal conditioned taste aversion behavior ( J:209690 )

• altered conditioned taste aversion to a low dose of ethanol

• however, response at higher doses is normal

abnormal anxiety-related response ( J:209690 )

• ethanol-treated mice fail to exhibit an increase in time spent in the open arms of an elevated plus maze unlike wild-type mice

• however, anxiety-related behavior is normal in saline-treated mice

nervous system

abnormal NMDA-mediated synaptic currents ( J:209690 )

• ethanol inhibition of NMDA current is intermediately impaired compared to in wild-type mice and homozygotes

• however, NMDA evoked currents are normal

taste/olfaction

taste/olfaction phenotype ( J:209690 )

N • mice exhibit normal saccharin preference