Phenotypes associated with this allele

• Allele Symbol: Diaph3^tm1.1Sna
• Allele Name: targeted mutation 1.1, Shuh Narumiya
• Allele ID: MGI:5574347
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Diaph3^tm1.1Sna/Diaph3^tm1.1Sna	B6NSlc.Cg-Diaph3^tm1.1Sna	MGI:5574353

Genotype
MGI:5574353

hm1

• Allelic Composition: Diaph3^tm1.1Sna/Diaph3^tm1.1Sna
• Genetic Background: B6NSlc.Cg-Diaph3^tm1.1Sna

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:205519 )

• die around E12.5

• no severe malformations before E10.5

embryo

decreased embryo size ( J:205519 )

• paler and smaller than controls at E11.5 but still viable

growth/size/body

decreased embryo size ( J:205519 )

• paler and smaller than controls at E11.5 but still viable

cardiovascular system

cardiovascular system phenotype ( J:205519 )

N • normal heart function and yolk sac blood vessels in embryos

hematopoietic system

extramedullary hematopoiesis ( J:205519 )

• fewer fetal RBC in the liver

• fewer burst forming erythroids and colony forming unit erythroids

• severely impaired cell proliferation amd increased apoptosis

• multinucleate late stage erythroblasts are increased

• less blood in yolk sac blood vessels than for controls

• larger, sometimes multinuclear blood cells

decreased erythroblast number ( J:205519 )

• normal elevation in numbers after 12 hours in culture

• considerably less increase in numbers than controls after 24 and 36 hours in culture

• proliferation rather than differentiation is disturbed

abnormal nucleated erythrocyte cell number ( J:205519 )

• enucleation of multinucleate erythroblasts is sometimes delayed

cellular

abnormal cell cycle ( J:205519 )

• frequent failure of cytokinesis during terminal differentiation of erythrocytes

• cleavage furrow forms but destabilizes

• aberrant localization of F actin sometimes