Phenotypes associated with this allele

• Allele Symbol: Esr1^tm1.1Ics
• Allele Name: targeted mutation 1.1, Mouse Clinical Institute
• Allele ID: MGI:5574591
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Esr1^tm1.1Ics/Esr1^tm1.1Ics	involves: C57BL/6NTac	MGI:5577256

Genotype
MGI:5577256

hm1

• Allelic Composition: Esr1^tm1.1Ics/Esr1^tm1.1Ics
• Genetic Background: involves: C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Ovary abnormalities in Esr1^tm1.1Ics/Esr1^tm1.1Ics females

growth/size/body

ovarian follicular cyst ( J:206373 )

• excess of large, hemorrhagic and/or cystic follicles in 10-12 weeks old mice

reproductive system

reproductive system phenotype ( J:206373 )

N • uterotrophic and epithelial endometrial cell proliferation responses to E2 are similar to controls

ovary hemorrhage ( J:206373 )

• excess of large, hemorrhagic and/or cystic follicles in 10-12 week old mice

abnormal ovary morphology ( J:206373 )

• reduced density of glandular interstitial cells

absent corpus luteum ( J:206373 )

• in 10-12 week old

decreased primordial ovarian follicle number ( J:206373 )

• decrease in the frequency of primordial follicles in 10-12 week old mice

• however, percentages of primary, secondary, and tertiary follicles are normal in 10-12 week old females

abnormal tertiary ovarian follicle morphology ( J:206373 )

• percentage of the tertiary follicle wall area composed of granulosa cells is decreased

• however, the thecal cell area is similar to controls

ovarian follicular cyst ( J:206373 )

• excess of large, hemorrhagic and/or cystic follicles in 10-12 weeks old mice

female infertility ( J:206373 )

cardiovascular system

ovary hemorrhage ( J:206373 )

• excess of large, hemorrhagic and/or cystic follicles in 10-12 week old mice

abnormal vascular endothelial cell physiology ( J:206373 )

• E2 treatment fails to stimulate endothelial repair

abnormal vasodilation ( J:206373 )

• no significant vasodilatory response after estradiol (E2) or estrogen-macromolecule conjugates (EDC) treatment unlike in wild-type controls

endocrine/exocrine glands

ovary hemorrhage ( J:206373 )

• excess of large, hemorrhagic and/or cystic follicles in 10-12 week old mice

abnormal ovary morphology ( J:206373 )

• reduced density of glandular interstitial cells

absent corpus luteum ( J:206373 )

• in 10-12 week old

decreased primordial ovarian follicle number ( J:206373 )

• decrease in the frequency of primordial follicles in 10-12 week old mice

• however, percentages of primary, secondary, and tertiary follicles are normal in 10-12 week old females

abnormal tertiary ovarian follicle morphology ( J:206373 )

• percentage of the tertiary follicle wall area composed of granulosa cells is decreased

• however, the thecal cell area is similar to controls

ovarian follicular cyst ( J:206373 )

• excess of large, hemorrhagic and/or cystic follicles in 10-12 weeks old mice

homeostasis/metabolism

increased circulating follicle stimulating hormone level ( J:206373 )

• tends to be increased in 10-12 week old females

increased circulating luteinizing hormone level ( J:206373 )

• markedly increased in 10-12 week old females

decreased circulating progesterone level ( J:206373 )

• markedly decreased in 10-12 week old females

muscle

abnormal vasodilation ( J:206373 )

• no significant vasodilatory response after estradiol (E2) or estrogen-macromolecule conjugates (EDC) treatment unlike in wild-type controls

cellular

abnormal cell migration ( J:206373 )

• absence of E2-stimulated cell migration in isolated endothelial cells