Phenotypes associated with this allele

• Allele Symbol: Apbb2^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:5574593
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Apbb2^tm1.1(KOMP)Vlcg/Apbb2^tm1.1(KOMP)Vlcg	C57BL/6N-Apbb2^tm1.1(KOMP)Vlcg/Ucd	MGI:5767563
ht2	Apbb2^tm1.1(KOMP)Vlcg/Apbb2^+	C57BL/6N-Apbb2^tm1.1(KOMP)Vlcg/Ucd	MGI:5797362

Genotype
MGI:5767563

hm1

• Allelic Composition: Apbb2^{tm1.1(KOMP)Vlcg}/Apbb2^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Apbb2^{tm1.1(KOMP)Vlcg}/Ucd
• Cell Lines: 14762A-E10

Data Sources

IMPC Data for Apbb2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

hemorrhage ( J:211773 )

IMPC - UCD

embryo

spina bifida ( J:211773 )

IMPC - UCD

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - UCD

nervous system

spina bifida ( J:211773 )

IMPC - UCD

Genotype
MGI:5797362

ht2

• Allelic Composition: Apbb2^{tm1.1(KOMP)Vlcg}/Apbb2⁺
• Genetic Background: C57BL/6N-Apbb2^{tm1.1(KOMP)Vlcg}/Ucd
• Cell Lines: 14762A-E10

Data Sources

IMPC Data for Apbb2

cardiovascular system

hemorrhage ( J:211773 )

IMPC - UCD

embryo

spina bifida ( J:211773 )

IMPC - UCD

growth/size/body

increased lung weight ( J:211773 )

♂

IMPC - UCD

homeostasis/metabolism

increased circulating alanine transaminase level ( J:211773 )

♀

IMPC - UCD

increased circulating aspartate transaminase level ( J:211773 )

♀

IMPC - UCD

integument

abnormal skin morphology ( J:211773 )

♂

IMPC - UCD

nervous system

spina bifida ( J:211773 )

IMPC - UCD

respiratory system

increased lung weight ( J:211773 )

♂

IMPC - UCD

vision/eye

abnormal eye morphology ( J:211773 )

♂

IMPC - UCD