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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Themism1Btlr
mutation 1, Bruce Beutler
MGI:5575394
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Themism1Btlr/Themism1Btlr C57BL/6J-Themism1Btlr MGI:5575396


Genotype
MGI:5575396
hm1
Allelic
Composition		 Themism1Btlr/Themism1Btlr
Genetic
Background		 C57BL/6J-Themism1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Themism1Btlr mutation (1 available); any Themis mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:211400 )
N
• mice exhibit normal immune response to NP-Ficoll
abnormal lymphocyte morphology ( J:211400 )
• increase in B to T cell ratio
decreased B-1a cell number ( J:211400 )
• decreased frequency
decreased CD4-positive, alpha-beta T cell number ( J:211400 )
• a decrease in the CD4+ to CD8+ T cell ratio caused by a diminished frequency of CD4+ T cells
impaired humoral immune response ( J:211400 )
• in response to ovalbumin administered with aluminum hydroxide
• however, response to Semliki Forest virus is normal

hematopoietic system
abnormal lymphocyte morphology ( J:211400 )
• increase in B to T cell ratio
decreased B-1a cell number ( J:211400 )
• decreased frequency
decreased CD4-positive, alpha-beta T cell number ( J:211400 )
• a decrease in the CD4+ to CD8+ T cell ratio caused by a diminished frequency of CD4+ T cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory