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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dlx2tm1.1Rth
targeted mutation 1.1, David H Rowitch
MGI:5575409
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Olig1tm1(cre)Rth/Olig1tm1(cre)Rth
Dlx1tm1Rth/Dlx1tm1Rth
Dlx2tm1.1Rth/Dlx2tm1.1Rth 		involves: 129S/SvEv * 129S4/SvJae * C57BL/6 MGI:5698611
cn2
 		Olig1tm1(cre)Rth/Olig1tm1(cre)Rth
Dlx1tm1Rth/Dlx1+
Dlx2tm1.1Rth/Dlx2+ 		involves: 129S/SvEv * 129S4/SvJae * C57BL/6 MGI:5698612


Genotype
MGI:5698611
cn1
Allelic
Composition		 Olig1tm1(cre)Rth/Olig1tm1(cre)Rth
Dlx1tm1Rth/Dlx1tm1Rth
Dlx2tm1.1Rth/Dlx2tm1.1Rth
Genetic
Background		 involves: 129S/SvEv * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlx1tm1Rth mutation (1 available); any Dlx1 mutation (21 available)
Dlx2tm1.1Rth mutation (1 available); any Dlx2 mutation (25 available)
Olig1tm1(cre)Rth mutation (1 available); any Olig1 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:212992 )
• mice are always dead before 21 days of age
neonatal lethality, incomplete penetrance ( J:212992 )
• mice fail to thrive and tend to die in the neonatal period




Genotype
MGI:5698612
cn2
Allelic
Composition		 Olig1tm1(cre)Rth/Olig1tm1(cre)Rth
Dlx1tm1Rth/Dlx1+
Dlx2tm1.1Rth/Dlx2+
Genetic
Background		 involves: 129S/SvEv * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlx1tm1Rth mutation (1 available); any Dlx1 mutation (21 available)
Dlx2tm1.1Rth mutation (1 available); any Dlx2 mutation (25 available)
Olig1tm1(cre)Rth mutation (1 available); any Olig1 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:212992 )
N
• mice survive to adulthood

nervous system
nervous system phenotype ( J:212992 )
N
• interneuron numbers tend to be more normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory