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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		n-TRtct5m1J
mutation 1, Jackson
MGI:5575489
Summary 22 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		n-TRtct5m1J/n-TRtct5m1J C57BL/6J MGI:5577058
cx2
 		Gabrg2tm1Spet/Gabrg2tm1Spet
n-TRtct5m1J/n-TRtct5m1J 		B6.129(Cg)-Gabrg2tm1Spet/Frk MGI:6511091
cx3
 		Gabrg2tm1Spet/Gabrg2tm1Spet
n-TRtct5m1J/n-TRtct5m1J
Tg(n-TRtct5)574Slac/0 		B6.129(Cg)-Gabrg2tm1Spet Tg(n-TRtct5)574Slac MGI:6511097
cx4
 		Gtpbp2tm1Ynim/Gtpbp2tm1Ynim
n-TRtct5m1J/n-TRtct5m1J 		B6.Cg-Gtpbp2tm1Ynim MGI:5581421
cx5
 		Gtpbp2nmf205/Gtpbp2nmf205
n-TRtct5m1J/n-TRtct5m1J 		C57BL/6J-Gtpbp2nmf205/J MGI:2681961
cx6
 		Gtpbp2nmf205/Gtpbp2+
n-TRtct5m1J/n-TRtct5m1J 		C57BL/6J-Gtpbp2nmf205/J MGI:5575490
cx7
 		Gtpbp2nmf205/Gtpbp2tm1Ynim
n-TRtct5m1J/n-TRtct5m1J 		(C57BL/6J-Gtpbp2nmf205/J x B6.Cg-Gtpbp2tm1Ynim)F1 MGI:5581408
cx8
 		Gtpbp2nmf205/Gtpbp2nmf205
n-TRtct5m1J/n-TRtct5m1J
Tg(n-TRtct1)516Slac/0 		C57BL/6J-Gtpbp2nmf205 Tg(n-TRtct1)516Slac MGI:6511084
cx9
 		Gtpbp2nmf205/Gtpbp2nmf205
n-TRtct5m1J/n-TRtct5m1J
Tg(n-TRtct2)557Slac/0 		C57BL/6J-Gtpbp2nmf205 Tg(n-TRtct2)557Slac MGI:6511088
cx10
 		n-TRtct5m1J/n-TRtct5m1J
Tg(n-TRtct1)310Slac/0 		C57BL/6J-Tg(n-TRtct1)310Slac MGI:6511071
cx11
 		n-TRtct5m1J/n-TRtct5m1J
Tg(n-TRtct1)516Slac/0 		C57BL/6J-Tg(n-TRtct1)516Slac MGI:6511073
cx12
 		n-TRtct5m1J/n-TRtct5m1J
Tg(n-TRtct2)529Slac/0 		C57BL/6J-Tg(n-TRtct2)529Slac MGI:6511078
cx13
 		n-TRtct5m1J/n-TRtct5m1J
Tg(n-TRtct2)557Slac/0 		C57BL/6J-Tg(n-TRtct2)557Slac MGI:6511081
cx14
 		n-TRtct5m1J/n-TRtct5m1J
Tg(n-TRtct5)574Slac/0 		C57BL/6J-Tg(n-TRtct5)574Slac MGI:6511064
cx15
 		Gtpbp2nmf205/Gtpbp2nmf205
n-TRtct5m1J/n-TRtct5+ 		involves: 129S1/SvImJ * C57BL/6J MGI:5576754
cx16
 		Gtpbp2nmf205/Gtpbp2nmf205
n-TRtct5m1J/n-TRtct5+ 		involves: A/J * C57BL/6J MGI:5576755
cx17
 		Gtpbp2nmf205/Gtpbp2nmf205
n-TRtct5m1J/n-TRtct5+ 		involves: AKR/J * C57BL/6J MGI:5576756
cx18
 		Gtpbp2nmf205/Gtpbp2nmf205
n-TRtct5m1J/n-TRtct5+ 		involves: C57BL/6J * C57BL/6NJ MGI:5576757
cx19
 		Gtpbp2nmf205/Gtpbp2nmf205
n-TRtct5m1J/n-TRtct5+ 		involves: C57BL/6J * CBA/J MGI:5576759
cx20
 		Gtpbp2nmf205/Gtpbp2nmf205
n-TRtct5m1J/n-TRtct5+ 		involves: C57BL/6J * DBA/2J MGI:5576765
cx21
 		Gtpbp2nmf205/Gtpbp2nmf205
n-TRtct5m1J/n-TRtct5+ 		involves: C57BL/6J * MA/MyJ MGI:5576769
cx22
 		Gtpbp2nmf205/Gtpbp2nmf205
n-TRtct5m1J/n-TRtct5+ 		involves: C57BL/6J * NOD/ShiLtJ MGI:5577057


Genotype
MGI:5577058
hm1
Allelic
Composition		 n-TRtct5m1J/n-TRtct5m1J
Genetic
Background		 C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
n-TRtct5m1J mutation (4 available); any n-TRtct5 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal seizure response to pharmacological agent ( J:297745 )
• higher seizure threshold when treated with pentylenetetrazole (PTZ)

cellular
abnormal ribosomal stalling ( J:211326 )
• compared with C57BL/6J congenic for wildtype n-Tr20 from C57BL/6NJ, extracts from the cerebellum of C57BL/6J inbred mice have more ribosomal pausing at AGA codons and 1.6 times the pausing magnitude at AGA codons

homeostasis/metabolism
abnormal ribosomal stalling ( J:211326 )
• compared with C57BL/6J congenic for wildtype n-Tr20 from C57BL/6NJ, extracts from the cerebellum of C57BL/6J inbred mice have more ribosomal pausing at AGA codons and 1.6 times the pausing magnitude at AGA codons

nervous system
abnormal seizure response to pharmacological agent ( J:297745 )
• higher seizure threshold when treated with pentylenetetrazole (PTZ)
abnormal synaptic transmission ( J:297745 )
• mEPSC frequency increase in CA1 region hippocampal neurons
• normal mEPSC amplitude and kinetics in CA1 region hippocampal neurons
• normal paired-pulse ratio (PPR) in CA1 region hippocampal neurons
abnormal miniature excitatory postsynaptic currents ( J:297745 )
• mEPSC frequency increase in CA1 region hippocampal neurons
• normal mEPSC amplitude and kinetics in CA1 region hippocampal neurons
abnormal paired-pulse inhibition ( J:297745 )
• reduced paired-pulse depression (PPD) at short interstimulus intervals in CA1 region hippocampal neurons




Genotype
MGI:6511091
cx2
Allelic
Composition		 Gabrg2tm1Spet/Gabrg2tm1Spet
n-TRtct5m1J/n-TRtct5m1J
Genetic
Background		 B6.129(Cg)-Gabrg2tm1Spet/Frk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabrg2tm1Spet mutation (3 available); any Gabrg2 mutation (41 available)
n-TRtct5m1J mutation (4 available); any n-TRtct5 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal spike wave discharge ( J:297745 )
• mild increase in SWD incidence
• normal SWD duration (i.e. same as on other genetic background)

nervous system
abnormal spike wave discharge ( J:297745 )
• mild increase in SWD incidence
• normal SWD duration (i.e. same as on other genetic background)




Genotype
MGI:6511097
cx3
Allelic
Composition		 Gabrg2tm1Spet/Gabrg2tm1Spet
n-TRtct5m1J/n-TRtct5m1J
Tg(n-TRtct5)574Slac/0
Genetic
Background		 B6.129(Cg)-Gabrg2tm1Spet Tg(n-TRtct5)574Slac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gabrg2tm1Spet mutation (3 available); any Gabrg2 mutation (41 available)
n-TRtct5m1J mutation (4 available); any n-TRtct5 mutation (4 available)
Tg(n-TRtct5)574Slac mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal spike wave discharge ( J:297745 )
• significant increase in SWD incidence
• normal SWD duration (i.e. same as on other genetic background)

nervous system
abnormal spike wave discharge ( J:297745 )
• significant increase in SWD incidence
• normal SWD duration (i.e. same as on other genetic background)




Genotype
MGI:5581421
cx4
Allelic
Composition		 Gtpbp2tm1Ynim/Gtpbp2tm1Ynim
n-TRtct5m1J/n-TRtct5m1J
Genetic
Background		 B6.Cg-Gtpbp2tm1Ynim
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gtpbp2tm1Ynim mutation (0 available); any Gtpbp2 mutation (38 available)
n-TRtct5m1J mutation (4 available); any n-TRtct5 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cerebellar layer morphology ( J:211326 )
• similar diminution of the cerebellum at 2 months of age is found as is found in nmf205 homozygotes and compound heterozygotes

cellular




Genotype
MGI:2681961
cx5
Allelic
Composition		 Gtpbp2nmf205/Gtpbp2nmf205
n-TRtct5m1J/n-TRtct5m1J
Genetic
Background		 C57BL/6J-Gtpbp2nmf205/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gtpbp2nmf205 mutation (1 available); any Gtpbp2 mutation (38 available)
n-TRtct5m1J mutation (4 available); any n-TRtct5 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal motor capabilities/coordination/movement ( J:82238 )
• an unsteady gait can be observed in mutant mice at approximately 6-9 weeks of age
ataxia ( J:211326 )
• truncal ataxia evident at 6 weeks of age

cellular
increased neuron apoptosis ( J:211326 )
• between 3 and 4 weeks of age progressive apoptosis of neurons in the inner granule layer is found, between 5 and 8 weeks of age apoptosis of granule cells in the dentate gyrus, CA2 pyramidal neurons, and layer IV cortical neurons are found, and many neorons in the retina including photoreceptors and amacrine, horizontal, and ganglion cells degenerate during this time
abnormal ribosomal stalling ( J:211326 )
• the point mutation in n-Tr20 results in decreased levels of processed n-Tr20 and increased levels of immature n-Tr20 over time, particularly in the cerebellum, and the reduction in the available pool of this isodecoder results in ribosomal stalling at AGA codons, which is exacerbated in the absence of functional GTPBP2

mortality/aging
premature death ( J:211326 )
• homozygotes die at 8 to 9 weeks of age

nervous system
increased neuron apoptosis ( J:211326 )
• between 3 and 4 weeks of age progressive apoptosis of neurons in the inner granule layer is found, between 5 and 8 weeks of age apoptosis of granule cells in the dentate gyrus, CA2 pyramidal neurons, and layer IV cortical neurons are found, and many neorons in the retina including photoreceptors and amacrine, horizontal, and ganglion cells degenerate during this time
abnormal hippocampus CA2 region morphology ( J:211326 )
• increased pyknotic nuclei are found in pyramidal neurons in the CA2 but not CA1 region of the hippocuampus
decreased cerebellar granule cell number ( J:211326 )
• progressive apoptosis of inner granule layer neurons is found between 3 and 4 weeks of age

vision/eye
abnormal retina morphology ( J:211326 )
• degeneration of many neurons in the retina occurs by 2 months of age, including photoreceptors, amacrine cells, horizontal cells, and ganglion cells

homeostasis/metabolism
abnormal ribosomal stalling ( J:211326 )
• the point mutation in n-Tr20 results in decreased levels of processed n-Tr20 and increased levels of immature n-Tr20 over time, particularly in the cerebellum, and the reduction in the available pool of this isodecoder results in ribosomal stalling at AGA codons, which is exacerbated in the absence of functional GTPBP2




Genotype
MGI:5575490
cx6
Allelic
Composition		 Gtpbp2nmf205/Gtpbp2+
n-TRtct5m1J/n-TRtct5m1J
Genetic
Background		 C57BL/6J-Gtpbp2nmf205/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gtpbp2nmf205 mutation (1 available); any Gtpbp2 mutation (38 available)
n-TRtct5m1J mutation (4 available); any n-TRtct5 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:211326 )
• no neurodegeneration was observed




Genotype
MGI:5581408
cx7
Allelic
Composition		 Gtpbp2nmf205/Gtpbp2tm1Ynim
n-TRtct5m1J/n-TRtct5m1J
Genetic
Background		 (C57BL/6J-Gtpbp2nmf205/J x B6.Cg-Gtpbp2tm1Ynim)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gtpbp2nmf205 mutation (1 available); any Gtpbp2 mutation (38 available)
Gtpbp2tm1Ynim mutation (0 available); any Gtpbp2 mutation (38 available)
n-TRtct5m1J mutation (4 available); any n-TRtct5 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cerebellum morphology ( J:211326 )
• the progressive neuronal apoptosis that results in smaller cerebellum, hippocampus CA2 region, dentate gyrus, and degeneration in the retina of nmf205 homozygotes is also found in this compound heterozygote




Genotype
MGI:6511084
cx8
Allelic
Composition		 Gtpbp2nmf205/Gtpbp2nmf205
n-TRtct5m1J/n-TRtct5m1J
Tg(n-TRtct1)516Slac/0
Genetic
Background		 C57BL/6J-Gtpbp2nmf205 Tg(n-TRtct1)516Slac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gtpbp2nmf205 mutation (1 available); any Gtpbp2 mutation (38 available)
n-TRtct5m1J mutation (4 available); any n-TRtct5 mutation (4 available)
Tg(n-TRtct1)516Slac mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:297745 )
N
• no neurodegeneration in brain




Genotype
MGI:6511088
cx9
Allelic
Composition		 Gtpbp2nmf205/Gtpbp2nmf205
n-TRtct5m1J/n-TRtct5m1J
Tg(n-TRtct2)557Slac/0
Genetic
Background		 C57BL/6J-Gtpbp2nmf205 Tg(n-TRtct2)557Slac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gtpbp2nmf205 mutation (1 available); any Gtpbp2 mutation (38 available)
n-TRtct5m1J mutation (4 available); any n-TRtct5 mutation (4 available)
Tg(n-TRtct2)557Slac mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:297745 )
N
• no neurodegeneration in brain




Genotype
MGI:6511071
cx10
Allelic
Composition		 n-TRtct5m1J/n-TRtct5m1J
Tg(n-TRtct1)310Slac/0
Genetic
Background		 C57BL/6J-Tg(n-TRtct1)310Slac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
n-TRtct5m1J mutation (4 available); any n-TRtct5 mutation (4 available)
Tg(n-TRtct1)310Slac mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:297745 )
N
• normal seizure threshold when treated with pentylenetetrazole (PTZ) [i.e. lower threshold than non-transgenic B6J mice, which carry the n-TRtct5m1J allele]




Genotype
MGI:6511073
cx11
Allelic
Composition		 n-TRtct5m1J/n-TRtct5m1J
Tg(n-TRtct1)516Slac/0
Genetic
Background		 C57BL/6J-Tg(n-TRtct1)516Slac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
n-TRtct5m1J mutation (4 available); any n-TRtct5 mutation (4 available)
Tg(n-TRtct1)516Slac mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:297745 )
• normal seizure threshold when treated with pentylenetetrazole (PTZ) [i.e. lower threshold than non-transgenic B6J mice, which carry the n-TRtct5m1J allele]




Genotype
MGI:6511078
cx12
Allelic
Composition		 n-TRtct5m1J/n-TRtct5m1J
Tg(n-TRtct2)529Slac/0
Genetic
Background		 C57BL/6J-Tg(n-TRtct2)529Slac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
n-TRtct5m1J mutation (4 available); any n-TRtct5 mutation (4 available)
Tg(n-TRtct2)529Slac mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:297745 )
• normal seizure threshold when treated with pentylenetetrazole (PTZ) [i.e. lower threshold than non-transgenic B6J mice, which carry the n-TRtct5m1J allele]




Genotype
MGI:6511081
cx13
Allelic
Composition		 n-TRtct5m1J/n-TRtct5m1J
Tg(n-TRtct2)557Slac/0
Genetic
Background		 C57BL/6J-Tg(n-TRtct2)557Slac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
n-TRtct5m1J mutation (4 available); any n-TRtct5 mutation (4 available)
Tg(n-TRtct2)557Slac mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:297745 )
• normal seizure threshold when treated with pentylenetetrazole (PTZ) [i.e. lower threshold than non-transgenic B6J mice, which carry the n-TRtct5m1J allele]




Genotype
MGI:6511064
cx14
Allelic
Composition		 n-TRtct5m1J/n-TRtct5m1J
Tg(n-TRtct5)574Slac/0
Genetic
Background		 C57BL/6J-Tg(n-TRtct5)574Slac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
n-TRtct5m1J mutation (4 available); any n-TRtct5 mutation (4 available)
Tg(n-TRtct5)574Slac mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:297745 )
N
• normal seizure threshold in response to electrical stimulation or when treated with pentylenetetrazole (PTZ) [i.e. lower threshold than non-transgenic B6J mice, which carry the n-TRtct5m1J allele]




Genotype
MGI:5576754
cx15
Allelic
Composition		 Gtpbp2nmf205/Gtpbp2nmf205
n-TRtct5m1J/n-TRtct5+
Genetic
Background		 involves: 129S1/SvImJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gtpbp2nmf205 mutation (1 available); any Gtpbp2 mutation (38 available)
n-TRtct5m1J mutation (4 available); any n-TRtct5 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:211326 )
• with one allele of n-Tr20 from 129/SvImJ in an F2 population, nmf205 homozygotes do not display the neurological phenotype seen on a pure C57BL/6J background




Genotype
MGI:5576755
cx16
Allelic
Composition		 Gtpbp2nmf205/Gtpbp2nmf205
n-TRtct5m1J/n-TRtct5+
Genetic
Background		 involves: A/J * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gtpbp2nmf205 mutation (1 available); any Gtpbp2 mutation (38 available)
n-TRtct5m1J mutation (4 available); any n-TRtct5 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:211326 )
• with one allele of n-Tr20 from A/J in an F2 population, nmf205 homozygotes do not display the neurological phenotype seen on a pure C57BL/6J background




Genotype
MGI:5576756
cx17
Allelic
Composition		 Gtpbp2nmf205/Gtpbp2nmf205
n-TRtct5m1J/n-TRtct5+
Genetic
Background		 involves: AKR/J * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gtpbp2nmf205 mutation (1 available); any Gtpbp2 mutation (38 available)
n-TRtct5m1J mutation (4 available); any n-TRtct5 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:211326 )
• with one allele of n-Tr20 from AKR/J in an F2 population, nmf205 homozygotes do not display the neurological phenotype seen on a pure C57BL/6J background




Genotype
MGI:5576757
cx18
Allelic
Composition		 Gtpbp2nmf205/Gtpbp2nmf205
n-TRtct5m1J/n-TRtct5+
Genetic
Background		 involves: C57BL/6J * C57BL/6NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gtpbp2nmf205 mutation (1 available); any Gtpbp2 mutation (38 available)
n-TRtct5m1J mutation (4 available); any n-TRtct5 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:211326 )
• with one allele of n-Tr20 from C57BL/6NJ in an F2 population, nmf205 homozygotes do not display the neurological phenotype seen on a pure C57BL/6J background




Genotype
MGI:5576759
cx19
Allelic
Composition		 Gtpbp2nmf205/Gtpbp2nmf205
n-TRtct5m1J/n-TRtct5+
Genetic
Background		 involves: C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gtpbp2nmf205 mutation (1 available); any Gtpbp2 mutation (38 available)
n-TRtct5m1J mutation (4 available); any n-TRtct5 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:211326 )
• with one allele of n-Tr20 from CBA/J in an F2 population, nmf205 homozygotes do not display the neurological phenotype seen on a pure C57BL/6J background




Genotype
MGI:5576765
cx20
Allelic
Composition		 Gtpbp2nmf205/Gtpbp2nmf205
n-TRtct5m1J/n-TRtct5+
Genetic
Background		 involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gtpbp2nmf205 mutation (1 available); any Gtpbp2 mutation (38 available)
n-TRtct5m1J mutation (4 available); any n-TRtct5 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:211326 )
• with one allele of n-Tr20 from DBA/2J in an F2 population, nmf205 homozygotes do not display the neurological phenotype seen on a pure C57BL/6J background




Genotype
MGI:5576769
cx21
Allelic
Composition		 Gtpbp2nmf205/Gtpbp2nmf205
n-TRtct5m1J/n-TRtct5+
Genetic
Background		 involves: C57BL/6J * MA/MyJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gtpbp2nmf205 mutation (1 available); any Gtpbp2 mutation (38 available)
n-TRtct5m1J mutation (4 available); any n-TRtct5 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:211326 )
• with one allele of n-Tr20 from MA/MyJ in an F2 population, nmf205 homozygotes do not display the neurological phenotype seen on a pure C57BL/6J background




Genotype
MGI:5577057
cx22
Allelic
Composition		 Gtpbp2nmf205/Gtpbp2nmf205
n-TRtct5m1J/n-TRtct5+
Genetic
Background		 involves: C57BL/6J * NOD/ShiLtJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gtpbp2nmf205 mutation (1 available); any Gtpbp2 mutation (38 available)
n-TRtct5m1J mutation (4 available); any n-TRtct5 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:211326 )
• with one allele of n-Tr20 from NOD/ShiLtJ in an F2 population, nmf205 homozygotes do not display the neurological phenotype seen on a pure C57BL/6J background




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory