Phenotypes associated with this allele

• Allele Symbol: Ctcf^tm1.1Gfili
• Allele Name: targeted mutation 1.1, Galina Filippova
• Allele ID: MGI:5575496
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ctcf^tm1.1Gfili/Ctcf^tm1.1Gfili	involves: 129S4/SvJaeSor * C57BL/6	MGI:5575502

Genotype
MGI:5575502

hm1

• Allelic Composition: Ctcf^tm1.1Gfili/Ctcf^tm1.1Gfili
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Ctcf^tm1.1Gfili/Ctcf^tm1.1Gfili embryos fail to develop beyond the E3.5 stage and undergo apoptosis

mortality/aging

embryonic lethality at implantation ( J:211097 )

• mice die between E4.5 and E5.5

embryo

increased embryonic tissue cell apoptosis ( J:211097 )

• in cultured E3.5 embryo explants

embryonic growth arrest ( J:211097 )

• E3.5 embryo explants fail to outgrow with no development of inner cell mass and trophoectoderm

absent inner cell mass ( J:211097 )

• does not develop in E3.5 embryo explants

absent trophectoderm ( J:211097 )

• does not develop in E3.5 embryo explants

cellular

increased embryonic tissue cell apoptosis ( J:211097 )

• in cultured E3.5 embryo explants