Phenotypes associated with this allele

• Allele Symbol: Raph1^tm1.1Makr
• Allele Name: targeted mutation 1.1, Matthias Krause
• Allele ID: MGI:5575553
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Raph1^tm1.1Makr/Raph1^tm1.1Makr	involves: C57BL/6NTac	MGI:5575558
cn2	Raph1^tm1.1Makr/Raph1^tm1.1Makr Tg(Pgk1-cre)1Lni/0	involves: BALB/c * C57BL/6 * C57BL/6NTac	MGI:5575561
cn3	Raph1^tm1.1Makr/Raph1^tm1.1Makr Tmem163^Tg(ACTB-cre)2Mrt/0 Tg(Dct-lacZ)A12Jkn/Tg(Dct-lacZ)A12Jkn	involves: C57BL/6 * C57BL/6NTac * CBA * FVB/N	MGI:5575559
cn4	Raph1^tm1.1Makr/Raph1^tm1.1Makr Tmem163^Tg(ACTB-cre)2Mrt/0	involves: C57BL/6 * C57BL/6NTac * FVB/N	MGI:5575560

Genotype
MGI:5575558

cn1

• Allelic Composition: Raph1^tm1.1Makr/Raph1^tm1.1Makr
• Genetic Background: involves: C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

impaired fibroblast cell migration ( J:208191 )

• in tamoxifen-treated mouse embryonic fibroblasts transduced with a retrovirus expressing an inducible cre

Genotype
MGI:5575561

cn2

• Allelic Composition: Raph1^tm1.1Makr/Raph1^tm1.1Makr; Tg(Pgk1-cre)1Lni/0
• Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6NTac

mortality/aging

neonatal lethality, incomplete penetrance ( J:208191 )

• Background Sensitivity: mice on a pure C57BL/6 genetic background (details not specified) tend to die shortly after birth unlike mice on a mixed background that are present in Mendelian ratios at P0

postnatal lethality, incomplete penetrance ( J:208191 )

• Background Sensitivity: fewer than expected mice on a mixed background are alive at P10 with many mice dying before 6 weeks of age

reproductive system

infertility ( J:208191 )

• Background Sensitivity: mice on a mixed background that reach sexual maturity are infertile

growth/size/body

decreased body size ( J:208191 )

pigmentation

belly spot ( J:208191 )

behavior/neurological

absent gastric milk in neonates ( J:208191 )

integument

belly spot ( J:208191 )

Genotype
MGI:5575559

cn3

• Allelic Composition: Raph1^tm1.1Makr/Raph1^tm1.1Makr; Tmem163^{Tg(ACTB-cre)2Mrt}/0; Tg(Dct-lacZ)A12Jkn/Tg(Dct-lacZ)A12Jkn
• Genetic Background: involves: C57BL/6 * C57BL/6NTac * CBA * FVB/N

pigmentation

belly spot ( J:208191 )

decreased melanocyte number ( J:208191 )

• in the trunk region at E14.5

growth/size/body

decreased body size ( J:208191 )

integument

belly spot ( J:208191 )

Genotype
MGI:5575560

cn4

• Allelic Composition: Raph1^tm1.1Makr/Raph1^tm1.1Makr; Tmem163^{Tg(ACTB-cre)2Mrt}/0
• Genetic Background: involves: C57BL/6 * C57BL/6NTac * FVB/N

Reduced body size in Raph1^tm1.1Makr/Raph1^tm1.1Makr Tmem163^{Tg(ACTB-cre)2Mrt}/0 mice

mortality/aging

postnatal lethality, incomplete penetrance ( J:208191 )

• some mice die within 4 weeks of birth

pigmentation

belly spot ( J:208191 )

growth/size/body

decreased body size ( J:208191 )

integument

belly spot ( J:208191 )