Phenotypes associated with this allele

• Allele Symbol: Gins4^tm1Ntak
• Allele Name: targeted mutation 1, Nobuyuki Takakura
• Allele ID: MGI:5575557
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gins4^tm1Ntak/Gins4^tm1Ntak	involves: 129P2/OlaHsd * C57BL/6	MGI:5575562
cx2	Gins4^tm1Ntak/Gins4^+ Tg(Krt19-Ptgs2,Krt19-Ptges)8Tko/0 Tg(Krt19-Wnt1)2Maos/0	involves: 129P2/OlaHsd * C3H * C57BL/6	MGI:5575638

Genotype
MGI:5575562

hm1

• Allelic Composition: Gins4^tm1Ntak/Gins4^tm1Ntak
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:209708 )

• embryos elicit hemorrhage in the decidua and die soon after implantation

cellular

increased inner cell mass apoptosis ( J:209708 )

• day 4 of blastocyst culture

decreased inner cell mass proliferation ( J:209708 )

• in blastocysts in culture

embryo

increased inner cell mass apoptosis ( J:209708 )

• day 4 of blastocyst culture

decreased inner cell mass proliferation ( J:209708 )

• in blastocysts in culture

Genotype
MGI:5575638

cx2

• Allelic Composition: Gins4^tm1Ntak/Gins4⁺; Tg(Krt19-Ptgs2,Krt19-Ptges)8Tko/0; Tg(Krt19-Wnt1)2Maos/0
• Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

neoplasm

decreased tumor growth/size ( J:209708 )

• as measured by weight of the stomachs and tumor