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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Chd5tm1.2Gmbr
targeted mutation 1.2, Garrett M Brodeur
MGI:5575642
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Chd5tm1.2Gmbr/Chd5tm1.2Gmbr involves: 129S4/SvJae MGI:5575651


Genotype
MGI:5575651
hm1
Allelic
Composition		 Chd5tm1.2Gmbr/Chd5tm1.2Gmbr
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chd5tm1.2Gmbr mutation (1 available); any Chd5 mutation (73 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal male germ cell morphology ( J:207846 )
• abnormally sloughed germ cells
teratozoospermia ( J:207846 )
• variable sperm morphology
abnormal spermatid morphology ( J:207846 )
• abnormal head
• round and elongated spermatids are sloughed
• abnormal condensation of chromatin
• high histone retention with decreased histone H4 hyperacetylation
decreased male germ cell number ( J:207846 )
• in the seminiferous epithelium
asthenozoospermia ( J:207846 )
• immotile sperm in some mice

reproductive system
reproductive system phenotype ( J:207846 )
N
• female mice exhibit normal fertility
abnormal male germ cell morphology ( J:207846 )
• abnormally sloughed germ cells
decreased male germ cell number ( J:207846 )
• in the seminiferous epithelium
asthenozoospermia ( J:207846 )
• immotile sperm in some mice
abnormal spermatogenesis ( J:207846 )
• beginning at stage IX, step 9
teratozoospermia ( J:207846 )
• variable sperm morphology
abnormal spermatid morphology ( J:207846 )
• abnormal head
• round and elongated spermatids are sloughed
• abnormal condensation of chromatin
• high histone retention with decreased histone H4 hyperacetylation
abnormal spermiation ( J:207846 )
• failure of spermiation
arrest of spermiogenesis ( J:207846 )
• in some mice

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:207846 )
N
• male mice exhibit normal testosterone levels




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory