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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tardbpm1H
mutation 1, Harwell
MGI:5575763
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tardbpm1H/Tardbpm1H involves: C3H/HeH * C57BL/6J MGI:5575772
ht2
 		Tardbpm1H/Tardbp+ involves: C3H/HeH * C57BL/6J MGI:5575773
cx3
 		Tardbpm1H/Tardbp+
Tg(SOD1*G93A)dl1Gur/0 		involves: C3H/HeH * C57BL/6 * C57BL/6J * SJL MGI:5575774


Genotype
MGI:5575772
hm1
Allelic
Composition		 Tardbpm1H/Tardbpm1H
Genetic
Background		 involves: C3H/HeH * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tardbpm1H mutation (2 available); any Tardbp mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:211620 )
• mice die prior to E6.5




Genotype
MGI:5575773
ht2
Allelic
Composition		 Tardbpm1H/Tardbp+
Genetic
Background		 involves: C3H/HeH * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tardbpm1H mutation (2 available); any Tardbp mutation (68 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
impaired muscle relaxation ( J:211620 )
• in the extensor digitorum longus
abnormal muscle tone ( J:211620 )
• soft abdominal body tone in male and female mice

behavior/neurological
limb grasping ( J:211620 )
• in female at 61 weeks
• however, male mice did not exhibit this phenotype but were not assessed beyond 52 weeks of age

nervous system
nervous system phenotype ( J:211620 )
N
• mice exhibit normal neuromuscular junctions in the abdomen and hindlimbs




Genotype
MGI:5575774
cx3
Allelic
Composition		 Tardbpm1H/Tardbp+
Tg(SOD1*G93A)dl1Gur/0
Genetic
Background		 involves: C3H/HeH * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tardbpm1H mutation (2 available); any Tardbp mutation (68 available)
Tg(SOD1*G93A)dl1Gur mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:211620 )
• as in Tg(SOD1*G93A)1Gur mice

muscle
decreased extensor digitorum longus weight ( J:211620 )
• compared with Tg(SOD1*G93A)1Gur mice
impaired muscle relaxation ( J:211620 )
• in the tibialis anterior compared with Tg(SOD1*G93A)1Gur mice
• however, relaxation time in the extensor digitorum longus is normal
abnormal muscle tone ( J:211620 )
• soft abdominal body tone as in Tardbpm1H heterozygotes

behavior/neurological
decreased grip strength ( J:211620 )
• as in Tg(SOD1*G93A)1Gur mice

growth/size/body
decreased body weight ( J:211620 )
• as in Tg(SOD1*G93A)1Gur mice

nervous system
nervous system phenotype ( J:211620 )
N
• mice exhibit normal numbers of motor neurons in the sciatic motor pool

limbs/digits/tail
decreased extensor digitorum longus weight ( J:211620 )
• compared with Tg(SOD1*G93A)1Gur mice




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory