Phenotypes associated with this allele

• Allele Symbol: Cygb^tm1Ppam
• Allele Name: targeted mutation 1, Pradeep PA Mammen
• Allele ID: MGI:5575764
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cygb^tm1Ppam/Cygb^tm1Ppam Tg(Myog-cre)1Eno/0	involves: 129 * C57BL/6	MGI:5575857

Genotype
MGI:5575857

cn1

• Allelic Composition: Cygb^tm1Ppam/Cygb^tm1Ppam; Tg(Myog-cre)1Eno/0
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Delayed regeneration of muscle in Cygb^tm1Ppam/Cygb^tm1Ppam Tg(Myog-cre)1Eno/0 mice after cardiotoxin injury

muscle

abnormal myoblast differentiation ( J:206378 )

• muscle progenitor cells are unable to differentiate fully in vitro

• full differentiation into myotubes is impaired in vitro

skeletal muscle degeneration ( J:206378 )

• prolonged muscle degeneration at 21 days after cardiotoxin-induced injury

abnormal muscle precursor cell physiology ( J:206378 )

• muscle progenitor cell proliferation is impaired in vitro

impaired muscle regeneration ( J:206378 )

• 14 days postinjury induced by cardiotoxin

cellular

increased apoptosis ( J:206378 )

• increase both in duration and magnitude of myocyte death after cardiotoxin-induced injury

abnormal myoblast differentiation ( J:206378 )

• muscle progenitor cells are unable to differentiate fully in vitro

• full differentiation into myotubes is impaired in vitro

decreased cell proliferation ( J:206378 )

• muscle progenitor cell proliferation is impaired in vitro

oxidative stress ( J:206378 )

• in muscles at 21 days post cardiotoxin-induced injury