Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-KCNQ1_i2)H08Desc
• Allele Name: transgene insertion H08, Denis Escande
• Allele ID: MGI:5575892
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Myh6-KCNQ1_i2)H08Desc/0	involves: FVB	MGI:5575894

Genotype
MGI:5575894

tg1

• Allelic Composition: Tg(Myh6-KCNQ1_i2)H08Desc/0
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased heart rate ( J:132483 )

• mice show ECG anomalies indicative of decreased heart rate, with age-related variation seen during the first 30 days of life, particularly between day 20 and 30, but remain stable between 1 month and 1 year of age, except for the P wave duration and slight increase in intrinsic sinus period

atrioventricular block ( J:132483 )

prolonged PR interval ( J:132483 )

prolonged QT interval ( J:132483 )

• QT interval prolongation, although to a lesser extent than in transgenic line H02

abnormal T wave ( J:132483 )

• the rapid component of the T wave is drastically prolonged

abnormal sinoatrial node conduction ( J:132483 )

• sinus node dysfunction as indicated by a longer intrinsic sinus period under autonomic nervous system blockade and an increase in minimum sinus period under isoproterenol infusion

prolonged P wave ( J:132483 )

• longer P wave duration than wild-type mice or transgenic line H05, but not as long as in transgenic line H02