All Phenotypes Col1a2<tm1b(EUCOMM)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Col1a2^{tm1b(EUCOMM)Wtsi}
targeted mutation 1b, Wellcome Trust Sanger Institute
MGI:5575901

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Col1a2^{tm1b(EUCOMM)Wtsi}/Col1a2^{tm1b(EUCOMM)Wtsi}	C57BL/6N-Col1a2^{tm1b(EUCOMM)Wtsi}/Bay	MGI:5756895
hm2	Col1a2^{tm1b(EUCOMM)Wtsi}/Col1a2^{tm1b(EUCOMM)Wtsi}	C57BL/6N-Col1a2^{tm1b(EUCOMM)Wtsi}/BayMmucd	MGI:6408308

Allelic Composition	Col1a2^{tm1b(EUCOMM)Wtsi}/Col1a2^{tm1b(EUCOMM)Wtsi}
Genetic Background	C57BL/6N-Col1a2^{tm1b(EUCOMM)Wtsi}/Bay
Cell Lines	EPD0536_7_E02

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a2^{tm1b(EUCOMM)Wtsi} mutation (1 available); any Col1a2 mutation (120 available)

Data Sources

IMPC Data for Col1a2

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

decreased total body fat amount ( J:211773 )

IMPC - BCM

cardiovascular system

increased heart weight ( J:211773 )

IMPC - BCM

dilated heart left ventricle ( J:211773 )

IMPC - BCM

growth/size/body

increased heart weight ( J:211773 )

IMPC - BCM

homeostasis/metabolism

decreased blood urea nitrogen level ( J:211773 )

IMPC - BCM

increased circulating alkaline phosphatase level ( J:211773 )

IMPC - BCM

limbs/digits/tail

abnormal femur morphology ( J:211773 )

IMPC - BCM

abnormal tibia morphology ( J:211773 )

IMPC - BCM

skeleton

abnormal femur morphology ( J:211773 )

IMPC - BCM

abnormal tibia morphology ( J:211773 )

IMPC - BCM

increased bone mineral content ( J:211773 )

IMPC - BCM

increased bone mineral density ( J:211773 )

IMPC - BCM

Allelic Composition	Col1a2^{tm1b(EUCOMM)Wtsi}/Col1a2^{tm1b(EUCOMM)Wtsi}
Genetic Background	C57BL/6N-Col1a2^{tm1b(EUCOMM)Wtsi}/BayMmucd
Cell Lines	EPD0536_7_E02

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a2^{tm1b(EUCOMM)Wtsi} mutation (1 available); any Col1a2 mutation (120 available)

Data Sources

IMPC Data for Col1a2

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased grip strength ( J:211773 )

IMPC - HAR

cardiovascular system

enlarged heart ( J:211773 )

IMPC - HAR

growth/size/body

enlarged heart ( J:211773 )

IMPC - HAR

enlarged spleen ( J:211773 )

IMPC - HAR

hematopoietic system

enlarged spleen ( J:211773 )

IMPC - HAR

decreased lymphocyte cell number ( J:211773 )

IMPC - HAR

increased leukocyte cell number ( J:211773 )

IMPC - HAR

increased neutrophil cell number ( J:211773 )

IMPC - HAR

increased large unstained cell number ( J:211773 )

IMPC - HAR

homeostasis/metabolism

increased circulating alkaline phosphatase level ( J:211773 )

IMPC - HAR

decreased circulating amylase level ( J:211773 )

IMPC - HAR

immune system

enlarged spleen ( J:211773 )

IMPC - HAR

decreased lymphocyte cell number ( J:211773 )

IMPC - HAR

increased leukocyte cell number ( J:211773 )

IMPC - HAR

increased neutrophil cell number ( J:211773 )

IMPC - HAR

increased large unstained cell number ( J:211773 )

IMPC - HAR

nervous system

abnormal optic disk morphology ( J:211773 )

IMPC - HAR

vision/eye

abnormal optic disk morphology ( J:211773 )

IMPC - HAR

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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