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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Insm1tm1.1(GFP/cre)Mgn
targeted mutation 1.1, Mark A Magnuson
MGI:5576020
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Insm1tm1.1(GFP/cre)Mgn/Insm1tm1.1(GFP/cre)Mgn involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL MGI:5576031
hm2
Insm1tm1.1(GFP/cre)Mgn/Insm1tm1.1(GFP/cre)Mgn involves: 129S6/SvEvTac * CD-1 * SJL MGI:5603596


Genotype
MGI:5576031
hm1
Allelic
Composition
Insm1tm1.1(GFP/cre)Mgn/Insm1tm1.1(GFP/cre)Mgn
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * CD-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insm1tm1.1(GFP/cre)Mgn mutation (1 available); any Insm1 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5603596
hm2
Allelic
Composition
Insm1tm1.1(GFP/cre)Mgn/Insm1tm1.1(GFP/cre)Mgn
Genetic
Background
involves: 129S6/SvEvTac * CD-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insm1tm1.1(GFP/cre)Mgn mutation (1 available); any Insm1 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die between E15.5 and E18.5, with about 10% surviving to E18.5

endocrine/exocrine glands
• only 8% of GFPCre-expressing endocrine cells are insulin positive at E18.5 and there is a decrease in cells expressing glucagon (from 24% to 11%), somatostatin (from 11% to 7%) and ghrelin (from 8% to 5%), indicating a possible defect in hormone production
• number of pancreatic polypeptide-positive cells is increased from 7% to 12% at E18.5
• size of the endocrine progenitor cells is increased at E18.5 and their shape becomes irregular
• endocrine progenitor cells are less differentiated
• endocrine cells remain closely associated with pancreatic ductal cells, indicating a defect of differentiating pre-endocrine cells to migrate away from pancreatic ductal regions
• endocrine progenitor cells show a slight decrease in proliferation (from 1.4% to 0.9%) at E15.5 and up to a 7-fold decrease at E18.5

cellular
• endocrine progenitor cells show a slight decrease in proliferation (from 1.4% to 0.9%) at E15.5 and up to a 7-fold decrease at E18.5





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory