Phenotypes associated with this allele

• Allele Symbol: Gnrhr^tm1.1Bhr
• Allele Name: targeted mutation 1.1, Richard R Behringer
• Allele ID: MGI:5576332
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gnrhr^tm1.1Bhr/Gnrhr^tm1.1Bhr	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J	MGI:5576342

Genotype
MGI:5576342

hm1

• Allelic Composition: Gnrhr^tm1.1Bhr/Gnrhr^tm1.1Bhr
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating gonadotropin level ( J:211771 )

decreased circulating follicle stimulating hormone level ( J:211771 )

• significantly reduced in male

• reduced 36% in females relative to controls

decreased circulating luteinizing hormone level ( J:211771 )

• significantly reduced in males

• Gnrhr agonists increase LH levels in plasma but less than in controls

• normal levels in females

reproductive system

reproductive system phenotype ( J:211771 )

♂N • complete spermatogenesis

♂N • males fertile

♂N • testis weight is comparable to controls

abnormal ovary morphology ( J:211771 )

♀

decreased corpora lutea number ( J:211771 )

♀ • corpora lutea are rare

increased tertiary ovarian follicle number ( J:211771 )

♀ • large numbers of antral follicles

abnormal male reproductive system morphology ( J:211771 )

♂

small testis ( J:211771 )

♂ • reduced testis size but still larger than Gnrhr^h males

♂ • testis histology normal

prolonged estrus ( J:211771 )

♀ • females are persistently in estrus

endocrine/exocrine glands

abnormal ovary morphology ( J:211771 )

♀

decreased corpora lutea number ( J:211771 )

♀ • corpora lutea are rare

increased tertiary ovarian follicle number ( J:211771 )

♀ • large numbers of antral follicles

small testis ( J:211771 )

♂ • reduced testis size but still larger than Gnrhr^h males

♂ • testis histology normal