Phenotypes associated with this allele

• Allele Symbol: Tmbim1^tm1Noj
• Allele Name: targeted mutation 1, Hiroshi Nojima
• Allele ID: MGI:5576384
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tmbim1^tm1Noj/Tmbim1^tm1Noj	B6.129S2-Tmbim1^tm1Noj	MGI:5576388

Genotype
MGI:5576388

hm1

• Allelic Composition: Tmbim1^tm1Noj/Tmbim1^tm1Noj
• Genetic Background: B6.129S2-Tmbim1^tm1Noj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:211693 )

N • mice exhibit normal blood pressure

abnormal aorta tunica media morphology ( J:211693 )

• overt thoracic aortic media degeneration with increased mucoid deposition and cysts in severely affected regions in aged mice

• however, no inflammation is observed

dilated aorta ( J:210916 )

♂ • internal circumference of thoracic aorta of aged, but not young, males is greater than in wild-type males indicating that older males are prone to aortic dilation

homeostasis/metabolism

abnormal circulating enzyme level ( J:210916 )

♂ • increase in plasma gelatinase levels in aged males

abnormal enzyme/coenzyme activity ( J:210916 )

♂ • gelatinolytic activity in the aortas of 17 month old males is increased compared to wild-type males