Phenotypes associated with this allele

• Allele Symbol: Xbp1^tm1.1Geno
• Allele Name: targeted mutation 1.1, Genoway
• Allele ID: MGI:5576515
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Xbp1^tm1.1Geno/Xbp1^tm1.1Geno Tg(Tek-cre)1Ywa/0	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:5576524

Genotype
MGI:5576524

cn1

• Allelic Composition: Xbp1^tm1.1Geno/Xbp1^tm1.1Geno; Tg(Tek-cre)1Ywa/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal retina blood vessel morphology ( J:211440 )

• larger avascular area at P7 without blood vessels extending from inner retina toward the outer retina compared with control mice

• the peripheral part of the outer retina remains nonvascularized at P14

abnormal physiological neovascularization ( J:211440 )

• following hindlimb ischemia and reperfusion, mice exhibit reduced neovascularization compared with control mice

decreased angiogenesis ( J:211440 )

• larger avascular area at P7 without blood vessels extending from inner retina toward the outer retina compared with control mice

• the peripheral part of the outer retina remains nonvascularized at P14

abnormal blood flow velocity ( J:211440 )

• following hindlimb ischemia and reperfusion, mice exhibit reduced blood flow compared with control mice

homeostasis/metabolism

abnormal response to injury ( J:211440 )

• following hindlimb ischemia and reperfusion, mice exhibit reduced blood flow, necrotic paw tip in 8 of 9 mice and reduced neovascularization compared with control mice

• however, transplantation with wild-type bone marrow increases blood reperfusion

vision/eye

abnormal retina blood vessel morphology ( J:211440 )

• larger avascular area at P7 without blood vessels extending from inner retina toward the outer retina compared with control mice

• the peripheral part of the outer retina remains nonvascularized at P14