Phenotypes associated with this allele

• Allele Symbol: Trp63^tm2.2Elrf
• Allele Name: targeted mutation 2.2, Elsa R Flores
• Allele ID: MGI:5576519
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trp63^tm2.2Elrf/Trp63^tm2.2Elrf	Not Specified	MGI:5576527
ht2	Trp63^tm2.2Elrf/Trp63^+	Not Specified	MGI:5576528

Genotype
MGI:5576527

hm1

• Allelic Composition: Trp63^tm2.2Elrf/Trp63^tm2.2Elrf
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:206433 )

• although born in a normal Mendelian ratio, all die within hours of birth

integument

abnormal epidermal layer morphology ( J:206433 )

• rudimentary stratified epithelium

• hyperproliferative epidermis

• colonies of epidermal cells in culture remain proliferative much longer, incorporating BrdU at high levels even at passage 5

abnormal epidermis stratum basale morphology ( J:206433 )

• expanded basal layer

• nests of basal epithelium in patches covering 20-30% of embryo

abnormal epidermis stratum spinosum morphology ( J:206433 )

• expanded spinous layer

dermal-epidermal separation ( J:206433 )

• fragile epidermis is easily detached from the dermis

Genotype
MGI:5576528

ht2

• Allelic Composition: Trp63^tm2.2Elrf/Trp63⁺
• Genetic Background: Not Specified

integument

abnormal epidermis stratum basale morphology ( J:206433 )

• expanded epidermal basal layer

wrinkled skin ( J:206433 )

• excess folds of skin