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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zap70rps
reduced protein stability
MGI:5576549
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Zap70mrtle/Zap70rps involves: C57BL/6 * C57BL/6JSfdAnu MGI:5576560
cx2
 		Foxp3tm2Ayr/?
Zap70rps/Zap70rps 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5576559


Genotype
MGI:5576560
ht1
Allelic
Composition		 Zap70mrtle/Zap70rps
Genetic
Background		 involves: C57BL/6 * C57BL/6JSfdAnu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zap70mrtle mutation (5 available); any Zap70 mutation (55 available)
Zap70rps mutation (0 available); any Zap70 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal double-positive T cell morphology ( J:211510 )
• reduced frequency of post-selection CD69+ double positive thymocytes
decreased CD8-positive, alpha-beta T cell number ( J:211510 )
• reduced percent in the percent thymus and spleen
abnormal regulatory T cell number ( J:211510 )
• reduced percent of Foxp3+ regulatory T cells within CD4+ single positive thymocytes
• percent of Foxp3+ regulatory T cells within CD4+ single positive lymphocytes in the spleen
abnormal CD4-positive, alpha beta T cell morphology ( J:211510 )
• CD4+ T cells exhibit blockage of calcium signaling compared with wild-type cells
decreased CD4-positive, alpha-beta T cell number ( J:211510 )
• reduced percent in the percent thymus and spleen

hematopoietic system
abnormal double-positive T cell morphology ( J:211510 )
• reduced frequency of post-selection CD69+ double positive thymocytes
decreased CD8-positive, alpha-beta T cell number ( J:211510 )
• reduced percent in the percent thymus and spleen
abnormal regulatory T cell number ( J:211510 )
• reduced percent of Foxp3+ regulatory T cells within CD4+ single positive thymocytes
• percent of Foxp3+ regulatory T cells within CD4+ single positive lymphocytes in the spleen
abnormal CD4-positive, alpha beta T cell morphology ( J:211510 )
• CD4+ T cells exhibit blockage of calcium signaling compared with wild-type cells
decreased CD4-positive, alpha-beta T cell number ( J:211510 )
• reduced percent in the percent thymus and spleen




Genotype
MGI:5576559
cx2
Allelic
Composition		 Foxp3tm2Ayr/?
Zap70rps/Zap70rps
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm2Ayr mutation (6 available); any Foxp3 mutation (58 available)
Zap70rps mutation (0 available); any Zap70 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:211510 )
N
• mice exhibit normal positive selection and thymus and spleen cellularity
abnormal T cell differentiation ( J:211510 )
• defects in thymocyte differentiation
abnormal double-positive T cell morphology ( J:211510 )
• reduced frequency of post-selection CD69+ double positive thymocytes
• however, the percent of CD4+CD8+ double positive thymocytes is normal
decreased CD8-positive, alpha-beta T cell number ( J:211510 )
• reduced percent in the percent spleen
• however, the percent in the thymus is normal
abnormal regulatory T cell number ( J:211510 )
• increased percent of Foxp3GFP within CD4+ T cells in the blood by 5 to 6 weeks
• reduced percent of Foxp3+ regulatory T cells within CD4+ single positive thymocytes
• reduced splenic regulatory T cell numbers that is not as severe as in the thymus indicating partial rebound
abnormal CD4-positive, alpha beta T cell morphology ( J:211510 )
• CD4+ T cells exhibit mild impairment calcium signaling with reduced duration of elevated intracellular calcium compared with wild-type cells
• however, peak intracellular calcium level is not reduced
decreased CD4-positive, alpha-beta T cell number ( J:211510 )
• reduced percent in the percent thymus spleen

hematopoietic system
abnormal T cell differentiation ( J:211510 )
• defects in thymocyte differentiation
abnormal double-positive T cell morphology ( J:211510 )
• reduced frequency of post-selection CD69+ double positive thymocytes
• however, the percent of CD4+CD8+ double positive thymocytes is normal
decreased CD8-positive, alpha-beta T cell number ( J:211510 )
• reduced percent in the percent spleen
• however, the percent in the thymus is normal
abnormal regulatory T cell number ( J:211510 )
• increased percent of Foxp3GFP within CD4+ T cells in the blood by 5 to 6 weeks
• reduced percent of Foxp3+ regulatory T cells within CD4+ single positive thymocytes
• reduced splenic regulatory T cell numbers that is not as severe as in the thymus indicating partial rebound
abnormal CD4-positive, alpha beta T cell morphology ( J:211510 )
• CD4+ T cells exhibit mild impairment calcium signaling with reduced duration of elevated intracellular calcium compared with wild-type cells
• however, peak intracellular calcium level is not reduced
decreased CD4-positive, alpha-beta T cell number ( J:211510 )
• reduced percent in the percent thymus spleen




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory