Phenotypes associated with this allele

• Allele Symbol: Sel1l^{tm1c(KOMP)Wtsi}
• Allele Name: targeted mutation 1c, Welcome Trust Sanger Institute
• Allele ID: MGI:5576558
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Sel1l^tm1c(KOMP)Wtsi/Sel1l^tm1c(KOMP)Wtsi Tg(CAG-cre/Esr1*)5Amc/0	involves: C57BL/6 * C57BL/6N * CBA * SJL	MGI:5581523

Genotype
MGI:5581523

cn1

• Allelic Composition: Sel1l^{tm1c(KOMP)Wtsi}/Sel1l^{tm1c(KOMP)Wtsi}; Tg(CAG-cre/Esr1*)5Amc/0
• Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * SJL
• Cell Lines: EPD0284_3_D08

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Exocrine pancreatic insufficiency in Sel1l^{tm1c(KOMP)Wtsi}/Sel1l^{tm1c(KOMP)Wtsi} Tg(CAG-cre/Esr1*)5Amc/0 mice

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:206568 )

• death within 2-3 weeks after a 3 day series of tamoxifen injections

moribund ( J:206568 )

• mice treated with tamoxifen become moribund

homeostasis/metabolism

steatorrhea ( J:206568 )

abnormal intestinal lipid absorption ( J:206568 )

• treated mice fail to properly absorb lipids

decreased body temperature ( J:206568 )

• mice treated with tamoxifen develop a reduced body temperature

increased susceptibility to xenobiotic induced morbidity/mortality ( J:206568 )

• death within 2-3 weeks after a 3 day series of tamoxifen injections

growth/size/body

decreased body size ( J:206568 )

• mice treated with tamoxifen become runted

postnatal growth retardation ( J:206568 )

• mice given three injected doses of tamoxifen start to lose weight about 8 days after the start of injections

• blood glucose and energy expenditure remain normal

behavior/neurological

increased food intake ( J:206568 )

digestive/alimentary system

abnormal exocrine pancreas morphology ( J:206568 )

• pancreas is diffusely dark red and soft at 8 days after treatment

exocrine pancreas atrophy ( J:206568 )

• weight is about 1/2 control pancreas weight

• dramatic morphological degeneration

• reduced eosinophilic secretory zymogen granules

• increased basophilia marked anisokaryosis and binucleate cells mild pancreatitis

steatorrhea ( J:206568 )

abnormal intestinal lipid absorption ( J:206568 )

• treated mice fail to properly absorb lipids

abnormal pancreatic acinar cell physiology ( J:206568 )

• alpha amylase and lipase levels significantly reduced

• activities reduced 60-80%

endocrine/exocrine glands

increased pancreas apoptosis ( J:206568 )

• 3-4 fold increase in TUNEL positive cells in the pancreas

abnormal exocrine pancreas morphology ( J:206568 )

• pancreas is diffusely dark red and soft at 8 days after treatment

exocrine pancreas atrophy ( J:206568 )

• weight is about 1/2 control pancreas weight

• dramatic morphological degeneration

• reduced eosinophilic secretory zymogen granules

• increased basophilia marked anisokaryosis and binucleate cells mild pancreatitis

abnormal pancreatic acinar cell physiology ( J:206568 )

• alpha amylase and lipase levels significantly reduced

• activities reduced 60-80%

cellular

abnormal cell morphology ( J:206568 )

• secretory zymogen granules are significantly reduced in size

• ratio of polysomes to monosomes is reduced by 50% after treatment

abnormal endoplasmic reticulum morphology ( J:206568 )

• extensively swollen and fragmented in pancreatic cells

increased cell death ( J:206568 )

• increased death of pancreatic exocrine cells by day 13 after tamoxifen injection

increased pancreas apoptosis ( J:206568 )

• 3-4 fold increase in TUNEL positive cells in the pancreas