Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(n-TRtct5)574Slac transgene insertion 574, Susan L Ackerman MGI:5576570 |
||||||||||||||||
| Summary |
3 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• significant increase in SWD incidence
• normal SWD duration (i.e. same as on other genetic background)
|
|
• significant increase in SWD incidence
• normal SWD duration (i.e. same as on other genetic background)
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• normal seizure threshold in response to electrical stimulation or when treated with pentylenetetrazole (PTZ) [i.e. lower threshold than non-transgenic B6J mice, which carry the n-TRtct5m1J allele]
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• although the cerebellum is not identical to Gtpbp2 wild-type controls, this transgene, which has brain-specific expression of wild-type n-Tr20, rescues most of the nmf205 mutant phenotype such that at 6 months of age the neuronal death is greatly attenuated in the brain and retina
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 12/10/2024 MGI 6.24 |
|
|
|
||
