Phenotypes associated with this allele

• Allele Symbol: Hprt1^{tm1(TG-cre)1Sasr}
• Allele Name: targeted mutation 1, Samia Selmi-Ruby
• Allele ID: MGI:5576753
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Thrb^tm1Mkni/Thrb^tm1Mkni Hprt1^tm1(TG-cre)1Sasr/Y	involves: 129/Sv * C57BL/6	MGI:5576933
cn2	Thrb^tm1Mkni/Thrb^+ Hprt1^tm1(TG-cre)1Sasr/Y	involves: 129/Sv * C57BL/6	MGI:5576934
ot3	Hprt1^tm1(TG-cre)1Sasr/Y	involves: C57BL/6	MGI:5576932

Genotype
MGI:5576933

cn1

• Allelic Composition: Thrb^tm1Mkni/Thrb^tm1Mkni; Hprt1^{tm1(TG-cre)1Sasr}/Y
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

decreased thyroid gland weight ( J:208718 )

♂ • significantly reduced at 2 months, compared to controls

growth/size/body

growth/size/body region phenotype ( J:208718 )

♂N • body weight is not different from wild-type in 2-month old males

homeostasis/metabolism

decreased circulating thyroid-stimulating hormone level ( J:208718 )

♂ • serum levels are decreased by 20%

abnormal thyroid hormone level ( J:208718 )

♂ • thyroid free T3 levels are not different from controls, but free rT3 levels are significantly elevated in the thyroid increased in 20 month old males; T4/rT3 ratios are elevated

increased thyroxine level ( J:208718 )

♂ • thyroid free T4 and thyroglobulin-bound T4 levels in the thyroid gland are significantly increased in 20 month old males; T4/T3 ratios are elevated

increased circulating levels of thyroid hormone ( J:208718 )

♂ • T3 levels are unchanged, but rT3 (reverse triiodothyronine) levels are significantly increased

increased circulating thyroxine level ( J:208718 )

♂ • serum levels are significantly increased at 2 months

Genotype
MGI:5576934

cn2

• Allelic Composition: Thrb^tm1Mkni/Thrb⁺; Hprt1^{tm1(TG-cre)1Sasr}/Y
• Genetic Background: involves: 129/Sv * C57BL/6

endocrine/exocrine glands

decreased thyroid gland weight ( J:208718 )

• significantly reduced at 2 months, compared to controls

Genotype
MGI:5576932

ot3

• Allelic Composition: Hprt1^{tm1(TG-cre)1Sasr}/Y
• Genetic Background: involves: C57BL/6

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:208718 )

♂N • thyroid weight and hormonal status (T3, T4, TSH) are not affected in 2-month or 1-year old males

growth/size/body

growth/size/body region phenotype ( J:208718 )

♂N • body weight is not different from wild-type in 2-month or 1-year old males