Phenotypes associated with this allele

• Allele Symbol: Tg(CAG-Ubqln1)2Hmw
• Allele Name: transgene insertion 2, Hongmin Wang
• Allele ID: MGI:5576803
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(CAG-Ubqln1)2Hmw/0	involves: C57BL/6 * SJL	MGI:5576879

Genotype
MGI:5576879

tg1

• Allelic Composition: Tg(CAG-Ubqln1)2Hmw/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased cellular sensitivity to oxidative stress ( J:206930 )

• increased tolerance of reactive oxygen species in liver at 2 months 6 hours post Menadione treatment

• decreased vacuolization, cell disruption, and karyolysis in liver sections at 2 months 6 hours post Menadione treatment

• decreased caspase-3 activity and neurodegeneration in brain cells and apoptotic cells in the cortex and the striatum at 2 months after 3 days of Menadione treatment

decreased hepatocyte apoptosis ( J:206930 )

• 6 hours post Menadione treatment

liver/biliary system

abnormal hepatocyte physiology ( J:206930 )

• increased tolerance of reactive oxygen species in liver at 2 months 6 hours post Menadione treatment

• decreased vacuolization, cell disruption, and karyolysis in liver sections at 2 months 6 hours post Menadione treatment

decreased hepatocyte apoptosis ( J:206930 )

• 6 hours post Menadione treatment

homeostasis/metabolism

abnormal response to CNS ischemic injury ( J:206930 )

• faster recovery of motor function following ischemic injury

decreased cerebral infarct size ( J:206930 )

• decreased ischemia/reperfusion-caused brain injury compared to wild-type

nervous system

abnormal response to CNS ischemic injury ( J:206930 )

• faster recovery of motor function following ischemic injury

decreased cerebral infarct size ( J:206930 )

• decreased ischemia/reperfusion-caused brain injury compared to wild-type