Phenotypes associated with this allele

• Allele Symbol: Ppargc1a^tm2.1Brsp
• Allele Name: targeted mutation 2.1, Bruce M Spiegelman
• Allele ID: MGI:5576884
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ppargc1a^tm2.1Brsp/Ppargc1a^tm2.1Brsp	involves: 129	MGI:5795605
cn2	Ppargc1a^tm2.1Brsp/Ppargc1a^tm2.1Brsp Tg(Myog-cre)1Eno/0	involves: 129 * BALB/c * C57BL/6J * C57BL/6N	MGI:5576914

Genotype
MGI:5795605

cn1

• Allelic Composition: Ppargc1a^tm2.1Brsp/Ppargc1a^tm2.1Brsp
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavioral response to amphetamine ( J:234906 )

• amphetamine induced ipsilateral turning fails to occur in mice treated with adenovirus expressing Cre recombinase

homeostasis/metabolism

decreased dopamine level ( J:234906 )

• mice injected with cre-expressing adenovirus into the ventral midbrain exhibit a 36.6% reduction in dopamine in the striatum

nervous system

decreased dopaminergic neuron number ( J:234906 )

• mice injected with cre-expressing adenovirus into the ventral midbrain exhibit a 51.7% reduction in TH-positive dopaminergic neurons of the substantial nigra pars compacta in 6 months

• mice injected with cre-expressing adenovirus into the ventral midbrain exhibit a 51.2% reduction in Nissl-stained neurons of the substantial nigra pars compacta in 6 months

Genotype
MGI:5576914

cn2

• Allelic Composition: Ppargc1a^tm2.1Brsp/Ppargc1a^tm2.1Brsp; Tg(Myog-cre)1Eno/0
• Genetic Background: involves: 129 * BALB/c * C57BL/6J * C57BL/6N

homeostasis/metabolism

decreased circulating glucose level ( J:208380 )

• at 3 and 12 months in fasting mice

decreased circulating insulin level ( J:208380 )

• at 3 and 24 months

decreased respiratory quotient ( J:208380 )

• in the dark phase only

impaired glucose tolerance ( J:208380 )

• in aged mice

• however, glucose tolerance is normal at 3 and 12 months

insulin resistance ( J:208380 )

• in aged mice

• however, insulin resistance is normal at 6 months

growth/size/body

growth/size/body region phenotype ( J:208380 )

N • mice exhibit normal body weight

decreased lean body mass ( J:208380 )

• in aged mice

cellular

abnormal mitochondrial physiology ( J:208380 )

• decreased succinate dehydrogenase activity in the gastrocnemius of young and old mice

adipose tissue

increased percent body fat/body weight ( J:208380 )

• in aged mice