Phenotypes associated with this allele

• Allele Symbol: Ryr2^tm1Krbr
• Allele Name: targeted mutation 1, Kenneth R Boheler
• Allele ID: MGI:5576915
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ryr2^tm1Krbr/Ryr2^tm1Krbr A1cf^Tg(Myh6-cre/Esr1*)1Jmk/A1cf^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	MGI:5576935
cn2	Ryr2^tm1Krbr/Ryr2^tm3.1Swch A1cf^Tg(Myh6-cre/Esr1*)1Jmk/A1cf^+	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:5606049

Genotype
MGI:5576935

cn1

• Allelic Composition: Ryr2^tm1Krbr/Ryr2^tm1Krbr; A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:210083 )

• tamoxifen-treated mice exhibit sudden cardiac death

cardiovascular system

decreased cardiac output ( J:210083 )

• in tamoxifen-treated mice

• however, compensatory mechanisms transiently ameliorate detrimental effects

abnormal sinus arrhythmia ( J:210083 )

• severe in tamoxifen-treated mice

decreased heart rate ( J:210083 )

• in tamoxifen-treated mice

sinus bradycardia ( J:210083 )

• in tamoxifen-treated mice

increased heart rate ( J:210083 )

• repetitive episodes of tachycardic arrhythmia in tamoxifen-treated mice

atrioventricular block ( J:210083 )

• secondary in tamoxifen-treated mice

abnormal T wave ( J:210083 )

• distinct T wave in tamoxifen-treated mice

cardiomyopathy ( J:210083 )

• in tamoxifen-treated mice

congestive heart failure ( J:210083 )

• in tamoxifen-treated mice

behavior/neurological

lethargy ( J:210083 )

• 4 days after tamoxifen treatment

homeostasis/metabolism

abnormal atrial thrombosis ( J:210083 )

• in tamoxifen-treated mice

muscle

cardiomyopathy ( J:210083 )

• in tamoxifen-treated mice

Genotype
MGI:5606049

cn2

• Allelic Composition: Ryr2^tm1Krbr/Ryr2^tm3.1Swch; A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

mortality/aging

premature death ( J:215190 )

• mice die starting around 11 days post tamoxifen injection, with most dying by day 14

cardiovascular system

decreased heart rate ( J:215190 )

• 12 days post tamoxifen treatment, mice exhibit a reduced basal heart rate

• tamoxifen treated mice, however, do not exhibit stress-induced (by caffeine or epinephrine) ventricular tachyarrhythmias at young or older ages