All Phenotypes Hprt1<tm4(CAG-Tbx18*,-Venus)Akis> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hprt1^{tm4(CAG-Tbx18*,-Venus)Akis}
targeted mutation 4, Andreas Kispert
MGI:5576943

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Hprt1^{tm4(CAG-Tbx18*,-Venus)Akis}/Y Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Tbx18^tm4(cre)Akis/Tbx18⁺	involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * NMRI	MGI:5576973
cn2	Hprt1^{tm4(CAG-Tbx18*,-Venus)Akis}/Y Tbx18^tm4(cre)Akis/Tbx18⁺	involves: 129S1/SvImJ * NMRI	MGI:5576974

Allelic Composition	Hprt1^{tm4(CAG-Tbx18*,-Venus)Akis}/Y Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Tbx18^tm4(cre)Akis/Tbx18⁺
Genetic Background	involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * NMRI

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (993 available)
Hprt1^{tm4(CAG-Tbx18*,-Venus)Akis} mutation (0 available); any Hprt1 mutation (1279 available)
Tbx18^tm4(cre)Akis mutation (0 available); any Tbx18 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal epicardium development ( J:210076 )

• epicardial cells exhibit premature smooth muscle cell differentiation and fail to invade into the right ventricular myocardium unlike in wild-type mice

Allelic Composition	Hprt1^{tm4(CAG-Tbx18*,-Venus)Akis}/Y Tbx18^tm4(cre)Akis/Tbx18⁺
Genetic Background	involves: 129S1/SvImJ * NMRI

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1^{tm4(CAG-Tbx18*,-Venus)Akis} mutation (0 available); any Hprt1 mutation (1279 available)
Tbx18^tm4(cre)Akis mutation (0 available); any Tbx18 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:210076 )

• mice die at E14.5

cardiovascular system

cardiovascular system phenotype ( J:210076 )

N	• cardiomyocytes apoptosis and size are normal

abnormal sinus venosus morphology ( J:210076 )

• sinus horn defects

heart hypoplasia ( J:210076 )

thin ventricle myocardium compact layer ( J:210076 )

• beginning at E12.5 and worsening at E14.5

abnormal pericardium morphology ( J:210076 )

decreased fetal cardiomyocyte proliferation ( J:210076 )

• in the right ventricular myocardium at E12.5 and E13.5

cellular

decreased fetal cardiomyocyte proliferation ( J:210076 )

• in the right ventricular myocardium at E12.5 and E13.5

muscle

thin ventricle myocardium compact layer ( J:210076 )

• beginning at E12.5 and worsening at E14.5

decreased fetal cardiomyocyte proliferation ( J:210076 )

• in the right ventricular myocardium at E12.5 and E13.5

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