All Phenotypes Traf3<m1Btlr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Traf3^m1Btlr
mutation 1, Bruce Beutler
MGI:5578024

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Traf3^m1Btlr/Traf3^m1Btlr	C57BL/6J-Traf3^m1Btlr	MGI:5578032

Allelic Composition	Traf3^m1Btlr/Traf3^m1Btlr
Genetic Background	C57BL/6J-Traf3^m1Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Traf3^m1Btlr mutation (1 available); any Traf3 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased mature B cell number ( J:212064 )

impaired humoral immune response ( J:212064 )

• mice lack a TD IgG response to OVA/alum

• however, mice exhibited a normal TD IgG response to a model antigen encoded by a replication deficient rSFV vector and NP-Ficoll

hematopoietic system

decreased mature B cell number ( J:212064 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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