Phenotypes associated with this allele

• Allele Symbol: Ltbr^m1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:5578031
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ltbr^m1Btlr/Ltbr^m1Btlr	C57BL/6J-Ltbr^m1Btlr	MGI:5578042

Genotype
MGI:5578042

hm1

• Allelic Composition: Ltbr^m1Btlr/Ltbr^m1Btlr
• Genetic Background: C57BL/6J-Ltbr^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell physiology ( J:212068 )

• mice lack a T-dependent (TD) IgG response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase vector

• however, mice exhibit a normal a T-dependent IgG response to aluminum hydroxide-emulsified ovalbumin (OVA-alum) and a normal T-independent (TI) IgM responses to 2,4,6-trinitrophenyl (NP)-Ficoll

abnormal humoral immune response ( J:212068 )

• mice lack a T-dependent (TD) IgG response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase vector

• however, mice exhibit a normal a T-dependent IgG response to aluminum hydroxide-emulsified ovalbumin (OVA-alum) and a normal T-independent (TI) IgM responses to 2,4,6-trinitrophenyl (NP)-Ficoll

hematopoietic system

abnormal B cell physiology ( J:212068 )

• mice lack a T-dependent (TD) IgG response to recombinant Semliki Forest virus (rSFV)-encoded beta-galactosidase vector

• however, mice exhibit a normal a T-dependent IgG response to aluminum hydroxide-emulsified ovalbumin (OVA-alum) and a normal T-independent (TI) IgM responses to 2,4,6-trinitrophenyl (NP)-Ficoll