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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tbc1d10ctm1.2Psou
targeted mutation 1.2, Pauline Soulas-Sprauel
MGI:5578034
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tbc1d10ctm1.2Psou/Tbc1d10ctm1.2Psou involves: 129S2/SvPas * C57BL/6J MGI:5578120
cn2
 		Tbc1d10ctm1.1Psou/Tbc1d10ctm1.2Psou
Cd79atm1(cre)Reth/Cd79a+ 		involves: 129S2/SvPas * BALB/c * C57BL/6J MGI:5578118
cn3
 		Tbc1d10ctm1.1Psou/Tbc1d10ctm1.2Psou
Tg(Lck-cre)#Nik/0 		involves: 129S2/SvPas * C57BL/6 * C57BL/6J * DBA/2 MGI:5578119


Genotype
MGI:5578120
hm1
Allelic
Composition		 Tbc1d10ctm1.2Psou/Tbc1d10ctm1.2Psou
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbc1d10ctm1.2Psou mutation (1 available); any Tbc1d10c mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:211913 )
N
• mice exhibit normal B and T cell development and basal secretion of immunoglobulins
• B cells do not exhibit spontaneous activation unlike T cells
• ovalbumin-treated mice exhibit normal germinal center kinetics
• mice treated with NP-LPS exhibit normal autoantibody production
abnormal B cell physiology ( J:211913 )
• accelerated antigen-specific B cell response in response to ovalbumin, NP-LPS and Borrelia burgdorferi infection
increased IgG level ( J:211913 )
• increased anti-ovalbumin IgG titer after ovalbumin treatment
• CpG-DNA-treated mice exhibit renal IgG deposits unlike wild-type mice
abnormal T cell activation ( J:211913 )
• spontaneous activation
increased T cell proliferation ( J:211913 )
• after stimulation with anti-CD3 or anti-CD3/anti-CD28 antibodies
increased susceptibility to systemic lupus erythematosus ( J:211913 )
• CpG-DNA-treated mice exhibit increased anti-double stranded DNA antibody levels and renal IgG deposits compared with control mice
increased anti-double stranded DNA antibody level ( J:211913 )
• in CpG-DNA-treated mice
• however, untreated mice do not produce autoantibodies and do not when treated with anti-thyroglobulin or anti-actin antibodies
abnormal response to infection ( J:211913 )
• Borrelia burgdorferi-infected mice exhibit enhanced IgG response compared with wild-type mice

hematopoietic system
abnormal B cell physiology ( J:211913 )
• accelerated antigen-specific B cell response in response to ovalbumin, NP-LPS and Borrelia burgdorferi infection
increased IgG level ( J:211913 )
• increased anti-ovalbumin IgG titer after ovalbumin treatment
• CpG-DNA-treated mice exhibit renal IgG deposits unlike wild-type mice
abnormal T cell activation ( J:211913 )
• spontaneous activation
increased T cell proliferation ( J:211913 )
• after stimulation with anti-CD3 or anti-CD3/anti-CD28 antibodies

cellular
increased T cell proliferation ( J:211913 )
• after stimulation with anti-CD3 or anti-CD3/anti-CD28 antibodies




Genotype
MGI:5578118
cn2
Allelic
Composition		 Tbc1d10ctm1.1Psou/Tbc1d10ctm1.2Psou
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background		 involves: 129S2/SvPas * BALB/c * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Tbc1d10ctm1.1Psou mutation (1 available); any Tbc1d10c mutation (19 available)
Tbc1d10ctm1.2Psou mutation (1 available); any Tbc1d10c mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell physiology ( J:211913 )
• accelerated antigen-specific B cell response in vivo in response to ovalbumin
increased IgG level ( J:211913 )
• increased anti-ovalbumin IgG titer after ovalbumin treatment
• CpG-DNA-treated mice exhibit renal IgG deposits unlike wild-type mice
increased IgM level ( J:211913 )
• in ovalbumin-treated mice
increased susceptibility to systemic lupus erythematosus ( J:211913 )
• CpG-DNA-treated mice exhibit increased anti-double stranded DNA antibody levels and renal IgG deposits compared with control mice
increased anti-double stranded DNA antibody level ( J:211913 )
• in CpG-DNA-treated mice
• however, untreated mice do not produce autoantibodies

hematopoietic system
abnormal B cell physiology ( J:211913 )
• accelerated antigen-specific B cell response in vivo in response to ovalbumin
increased IgG level ( J:211913 )
• increased anti-ovalbumin IgG titer after ovalbumin treatment
• CpG-DNA-treated mice exhibit renal IgG deposits unlike wild-type mice
increased IgM level ( J:211913 )
• in ovalbumin-treated mice




Genotype
MGI:5578119
cn3
Allelic
Composition		 Tbc1d10ctm1.1Psou/Tbc1d10ctm1.2Psou
Tg(Lck-cre)#Nik/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbc1d10ctm1.1Psou mutation (1 available); any Tbc1d10c mutation (19 available)
Tbc1d10ctm1.2Psou mutation (1 available); any Tbc1d10c mutation (19 available)
Tg(Lck-cre)#Nik mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:211913 )
N
• mice exhibit normal early antigen-specific B cell response




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory