Phenotypes associated with this allele

• Allele Symbol: Rab8b^tm1.2Aha
• Allele Name: targeted mutation 1.2, Akihiro Harada
• Allele ID: MGI:5578141
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rab8b^tm1.2Aha/Rab8b^tm1.2Aha	involves: BALB/cJ * C57BL/6 * SJL	MGI:5578144
cx2	Rab8a^tm1.2Aha/Rab8a^tm1.2Aha Rab8b^tm1.2Aha/Rab8b^tm1.2Aha	involves: BALB/cJ * C57BL/6 * SJL	MGI:5578146

Genotype
MGI:5578144

hm1

• Allelic Composition: Rab8b^tm1.2Aha/Rab8b^tm1.2Aha
• Genetic Background: involves: BALB/cJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:211898 )

• mice do not display any overt abnormalities with normal survival

Genotype
MGI:5578146

cx2

• Allelic Composition: Rab8a^tm1.2Aha/Rab8a^tm1.2Aha; Rab8b^tm1.2Aha/Rab8b^tm1.2Aha
• Genetic Background: involves: BALB/cJ * C57BL/6 * SJL

mortality/aging

postnatal lethality, complete penetrance ( J:211898 )

• mice gradually die 2 weeks after birth

digestive/alimentary system

abnormal small intestinal microvillus morphology ( J:211898 )

• atrophic with inclusions at P14

cellular

cellular phenotype ( J:211898 )

N • mice exhibit normal length and morphology of cilia on mouse embryonic fibroblasts

respiratory system

respiratory system phenotype ( J:211898 )

N • mice exhibit normal motile cilia in the trachea

vision/eye

vision/eye phenotype ( J:211898 )

N • mice exhibit normal motile cilia in the retina