Phenotypes associated with this allele

• Allele Symbol: C1qtnf3^tm1Yiw
• Allele Name: targeted mutation 1, Yoichiro Iwakura
• Allele ID: MGI:5578157
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	C1qtnf3^tm1Yiw/C1qtnf3^tm1Yiw	involves: C57BL/6NSlc	MGI:5578162

Genotype
MGI:5578162

hm1

• Allelic Composition: C1qtnf3^tm1Yiw/C1qtnf3^tm1Yiw
• Genetic Background: involves: C57BL/6NSlc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:211893 )

N • mice exhibit normal anti-IgM-induced B cell proliferation and neutrophil activation

increased IgG level ( J:211893 )

• increased collagen-specific IgG levels in collagen-treated mice

joint inflammation ( J:211893 )

• increased in collagen-treated mice

increased susceptibility to induced arthritis ( J:211893 )

• mice treated with collagen exhibit increased incidents of arthritis with increased clinical scores and increased anti-collagen IgG levels compared to in wild-type mice

• however, mice exhibit normal plasma C3a and C5a levels and T cell priming

skeleton

joint inflammation ( J:211893 )

• increased in collagen-treated mice

increased susceptibility to induced arthritis ( J:211893 )

• mice treated with collagen exhibit increased incidents of arthritis with increased clinical scores and increased anti-collagen IgG levels compared to in wild-type mice

• however, mice exhibit normal plasma C3a and C5a levels and T cell priming

hematopoietic system

increased IgG level ( J:211893 )

• increased collagen-specific IgG levels in collagen-treated mice