Phenotypes associated with this allele

• Allele Symbol: Cgas^{tm1d(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1d, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5578170
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cgas^tm1d(EUCOMM)Hmgu/Cgas^tm1d(EUCOMM)Hmgu	involves: BALB/c * C57BL/6JJcl * C57BL/6N	MGI:5578172
hm2	Cgas^tm1d(EUCOMM)Hmgu/Cgas^tm1d(EUCOMM)Hmgu	involves: C57BL/6N	MGI:6401488

Genotype
MGI:5578172

hm1

• Allelic Composition: Cgas^{tm1d(EUCOMM)Hmgu}/Cgas^{tm1d(EUCOMM)Hmgu}
• Genetic Background: involves: BALB/c * C57BL/6JJcl * C57BL/6N
• Cell Lines: HEPD0516_3_C04

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to Poxviridae infection induced morbidity/mortality ( J:207826 )

• mice infected with vaccinia virus exhibit increased mortality compared with wild-type mice

increased susceptibility to Flaviviridae infection induced morbidity/mortality ( J:207826 )

• mice infected with West Nile Virus (WNV) exhibit increased lethality compared with wild-type mice

immune system

increased susceptibility to Herpesvirales infection ( J:207826 )

• mice infected with murine gamma herpes virus 68 (MHV68) exhibit a 2.0-fold higher viral titer in the spleen and 3.5-fold in the lungs compared with wild-type mice

• bone marrow derived macrophages infected with MHV68exhibit increased viral titers compared with wild-type mice

increased susceptibility to Poxviridae infection ( J:207826 )

• mice infected with vaccinia virus (VV) exhibit increased mortality compared with wild-type mice

• bone marrow derived macrophages infected with VV exhibit increased viral titers compared with wild-type mice

increased susceptibility to Poxviridae infection induced morbidity/mortality ( J:207826 )

• mice infected with vaccinia virus exhibit increased mortality compared with wild-type mice

increased susceptibility to Flaviviridae infection ( J:207826 )

• mice infected with WNV exhibit increased lethality compared with wild-type mice

• bone marrow derived macrophages infected with West Nile Virus (WNV) exhibit increased viral titers compared with wild-type mice

• however, mice infected with WNV exhibit normal viral titers

increased susceptibility to Flaviviridae infection induced morbidity/mortality ( J:207826 )

• mice infected with West Nile Virus (WNV) exhibit increased lethality compared with wild-type mice

Genotype
MGI:6401488

hm2

• Allelic Composition: Cgas^{tm1d(EUCOMM)Hmgu}/Cgas^{tm1d(EUCOMM)Hmgu}
• Genetic Background: involves: C57BL/6N

hematopoietic system

hematopoietic system phenotype ( J:265023 )

N • normal response by bone marrow-derived macrophages (BMDMs) to LPS, poly(I.C) and cGAMP

immune system

immune system phenotype ( J:265023 )

N • normal response by bone marrow-derived macrophages (BMDMs) to LPS, poly(I.C) and cGAMP

increased susceptibility to Retroviridae infection ( J:265023 )

• lack of interferon beta surge in bone marrow-derived macrophages (BMDMs) and bone marrow dendritic cells (BMDCs) from MLV (murine leukemia virus) or HIV-infected mice

• higher infection levels in draining lymph node after subcutaneous inoculation with MLV (murine leukemia virus)

• 5x higher virus titers in spleen 16 days after inoculation of newborn pups with MLV (murine leukemia virus)