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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Stat4ity14
immunity to Typhimurium locus 14
MGI:5578183
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Stat4ity14/Stat4ity14 involves: 129S1/Sv * 129X1/SvJ MGI:5578206
ht2
 		Stat4ity14/Stat4tm1Gru involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ MGI:5578205


Genotype
MGI:5578206
hm1
Allelic
Composition		 Stat4ity14/Stat4ity14
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat4ity14 mutation (0 available); any Stat4 mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to bacterial infection induced morbidity/mortality ( J:207092 )
• mice infected with Salmonella Typhimurium exhibit increased lethality compared with wild-type mice

immune system
decreased circulating interferon-gamma level ( J:207092 )
• in mice infected with Salmonella Typhimurium
increased circulating interleukin-12 level ( J:207092 )
• in mice infected with Salmonella Typhimurium
decreased interferon-gamma secretion ( J:207092 )
• from splenocytes stimulated with IL12
increased susceptibility to bacterial infection ( J:207092 )
• mice infected with Salmonella Typhimurium exhibit increased lethality, impaired systemic IFN-gamma secretion, fewer and smaller microabscess in the liver and increased bacterial burden in the spleen (17.2-fold) and liver (87.3-fold) compared with wild-type mice
• 4 days after Salmonella infection, mice exhibit less submucosal edema, less PMN cell infiltration of the lamina propria, increased goblet cells count and decreased epithelial integrity compared with wild-type mice
increased susceptibility to bacterial infection induced morbidity/mortality ( J:207092 )
• mice infected with Salmonella Typhimurium exhibit increased lethality compared with wild-type mice

homeostasis/metabolism
decreased circulating interferon-gamma level ( J:207092 )
• in mice infected with Salmonella Typhimurium
increased circulating interleukin-12 level ( J:207092 )
• in mice infected with Salmonella Typhimurium




Genotype
MGI:5578205
ht2
Allelic
Composition		 Stat4ity14/Stat4tm1Gru
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat4ity14 mutation (0 available); any Stat4 mutation (64 available)
Stat4tm1Gru mutation (4 available); any Stat4 mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to bacterial infection induced morbidity/mortality ( J:207092 )
• mice infected with Salmonella Typhimurium exhibit increased lethality compared with wild-type mice

mortality/aging
increased susceptibility to bacterial infection induced morbidity/mortality ( J:207092 )
• mice infected with Salmonella Typhimurium exhibit increased lethality compared with wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory