All Phenotypes Mgat4b<tm1.1Jxm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mgat4b^tm1.1Jxm
targeted mutation 1.1, Jamey Marth
MGI:5578604

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mgat4b^tm1.1Jxm/Mgat4b^tm1.1Jxm	B6.129-Mgat4b^tm1.1Jxm	MGI:5578636
cx2	Mgat4a^tm1.1Jxm/Mgat4a^tm1.1Jxm Mgat4b^tm1.1Jxm/Mgat4b^tm1.1Jxm	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5578637

Allelic Composition	Mgat4b^tm1.1Jxm/Mgat4b^tm1.1Jxm
Genetic Background	B6.129-Mgat4b^tm1.1Jxm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mgat4b^tm1.1Jxm mutation (0 available); any Mgat4b mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased mean corpuscular hemoglobin ( J:212313 )

increased mean corpuscular volume ( J:212313 )

decreased red blood cell distribution width ( J:212313 )

decreased neutrophil cell number ( J:212313 )

increased leukocyte cell number ( J:212313 )

homeostasis/metabolism

decreased circulating VLDL cholesterol level ( J:212313 )

abnormal circulating protein level ( J:212313 )

• increased Protein C (factor XIV)

• reduced factor V (10-20% decrease as compared to wild-type)

• reduced factor VII (10-20% decrease as compared to wild-type

• reduced factor XII (10-20% decrease as compared to wild-type)

• increased Protein S

decreased circulating factor IX level ( J:212313 )

• reduced factor IX (10-20% decrease as compared to wild-type)

decreased circulating factor VIII level ( J:212313 )

• reduced factor VIII (30% decrease as compared to wild-type)

decreased circulating prothrombin level ( J:212313 )

• reduced factor II (10-20% decrease as compared to wild-type)

decreased circulating von Willebrand factor level ( J:212313 )

• reduced factor vWF (30% decrease as compared to wild-type)

increased bleeding time ( J:212313 )

increased partial thromboplastin time ( J:212313 )

• activated partial thromboplastin time (APTT) is slightly prolonged although normal prothrombin time is unaffected

immune system

decreased neutrophil cell number ( J:212313 )

increased leukocyte cell number ( J:212313 )

Allelic Composition	Mgat4a^tm1.1Jxm/Mgat4a^tm1.1Jxm Mgat4b^tm1.1Jxm/Mgat4b^tm1.1Jxm
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mgat4a^tm1.1Jxm mutation (0 available); any Mgat4a mutation (34 available)
Mgat4b^tm1.1Jxm mutation (0 available); any Mgat4b mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

hyperglycemia ( J:212313 )

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