Phenotypes associated with this allele

• Allele Symbol: Tmprss2^{tm2.1(ETV1)Sho}
• Allele Name: targeted mutation 2.1, Stuart Orkin
• Allele ID: MGI:5578607
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tmprss2^tm2.1(ETV1)Sho/Tmprss2^tm2.1(ETV1)Sho	involves: C57BL/6 * DBA/2	MGI:5578647
cn2	Pten^tm1Hwu/Pten^+ Tmprss2^tm2.1(ETV1)Sho/Tmprss2^tm2.1(ETV1)Sho Tg(Pbsn-cre)4Prb/0	involves: 129S4/SvJae * C57BL/6 * DBA/2	MGI:5578649
cx3	Pten^tm1.1Hwu/Pten^+ Tmprss2^tm2.1(ETV1)Sho/Tmprss2^tm2.1(ETV1)Sho	involves: 129S4/SvJae * C57BL/6 * DBA/2	MGI:5578648

Genotype
MGI:5578647

hm1

• Allelic Composition: Tmprss2^{tm2.1(ETV1)Sho}/Tmprss2^{tm2.1(ETV1)Sho}
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:212219 )

♂N • prostates are largely normal and do not develop prostatic intraepithelial neoplasia (PIN) lesions or cancer

prostate gland inflammation ( J:212219 )

♂ • in 4 of 11 mice

homeostasis/metabolism

abnormal testosterone level ( J:212219 )

♂ • castrated mice exhibit higher levels of testosterone in prostate cells compared with castrated wild-type mice

♂ • however, non-castrated mice exhibit normal testosterone levels

neoplasm

neoplasm ( J:212219 )

♂N • prostates do not develop prostatic intraepithelial neoplasia (PIN) lesions or cancer

immune system

prostate gland inflammation ( J:212219 )

♂ • in 4 of 11 mice

endocrine/exocrine glands

prostate gland inflammation ( J:212219 )

♂ • in 4 of 11 mice

Genotype
MGI:5578649

cn2

• Allelic Composition: Pten^tm1Hwu/Pten⁺; Tmprss2^{tm2.1(ETV1)Sho}/Tmprss2^{tm2.1(ETV1)Sho}; Tg(Pbsn-cre)4Prb/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

mortality/aging

premature death ( J:212219 )

♂ • most mice die before 1 year of age

reproductive system

increased prostate gland adenocarcinoma incidence ( J:212219 )

♂ • invasive with metastasis into the prostate stroma and urogenital area

prostate gland cyst ( J:212219 )

♂ • large

neoplasm

increased prostate gland adenocarcinoma incidence ( J:212219 )

♂ • invasive with metastasis into the prostate stroma and urogenital area

endocrine/exocrine glands

increased prostate gland adenocarcinoma incidence ( J:212219 )

♂ • invasive with metastasis into the prostate stroma and urogenital area

prostate gland cyst ( J:212219 )

♂ • large

growth/size/body

prostate gland cyst ( J:212219 )

♂ • large

Genotype
MGI:5578648

cx3

• Allelic Composition: Pten^tm1.1Hwu/Pten⁺; Tmprss2^{tm2.1(ETV1)Sho}/Tmprss2^{tm2.1(ETV1)Sho}
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:212219 )

♂

endocrine/exocrine glands

increased prostate intraepithelial neoplasia incidence ( J:212219 )

♂

reproductive system

increased prostate intraepithelial neoplasia incidence ( J:212219 )

♂