homeostasis/metabolism
N |
• mice exhibit normal plasma ACTH, adiponectin and phosphate levels
|
• overt diabetes mellitus in most mice
|
|
• in female, but not male, mice
|
|
• in female, but not male, mice
|
• in fasted mice at 8, 12 and 16 weeks
|
• at 12 weeks in female and male mice
|
• in female and male mice at 8 to 12 weeks
|
• in 24 week old mice after a 4-hour fast
|
• in 24 week old mice after a 4-hour fast
|
• in female and male mice at 8 to 12 weeks
|
• mild in female and male
|
• in female and male
|
|
• in male, but not female, mice
|
|
• in female, but not male, mice
|
• by 19 weeks with frustosamine concentrations
|
• in fasted female and male mice at 8 weeks
• persisting at 12 and 16 weeks
|
• likely insulin resistance due to increased adiposity
|
• diminution of corticosterone circadian rhythm
|
• in female and male mice
|
• peak concentration is 8-fold greater than the nadir value
|
• in female, but not male, mice
|
skeleton
• increased adipocytes in the bone marrow
|
• with reduced percentage of corticoendosteal bone covered by osteoblasts
|
• reduced mineral apposition rates
• reduced mineralization surface area
|
• reduced bone formation rates
|
growth/size/body
• from 5 weeks in female and male mice
|
|
• in male mice only at 5 weeks
|
|
• in female mice from 6 weeks on
|
renal/urinary system
• in female and male mice
|
• peak concentration is 8-fold greater than the nadir value
|
• in female, but not male, mice
|
behavior/neurological
polydipsia
(
J:208708
)
|
• in male, but not female, mice
|
liver/biliary system
• moderate diffuse microvesicular vacuolation
|
adipose tissue
• from 5 weeks in female and male mice
|
• increased adipocytes in the bone marrow
|
endocrine/exocrine glands
• hypertrophic
|
• increased weight
|
integument
limbs/digits/tail
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
primary hyperaldosteronism | DOID:446 |
OMIM:605635 OMIM:613677 |
J:208708 |