Analysis Tools|
Allele Symbol Allele Name Allele ID |
Nsdhltm1.1Hrm targeted mutation 1.1, Gail Herman MGI:5581334 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• patches of hairless skin
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• patches of hyperkeratotic skin
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• skeletal abnormalities
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• growth curve falls behind controls starting around P7
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• die between P12-P20
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• thinner with fewer granule cell precursors at P5 and becoming progressively worse with age
• at P8 only a single layer of granule cell precursors is present in severely affected mice
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• appears disorganized with fewer hippocampal neurons
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• fewer neurons present in the dentate gyrus at P0
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• fewer hippocampal neurons at P0 especially in the dentate gyrus
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• reduced numbers and organization of granule neurons at P7
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• at P7
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• at P7
• increase in pycnotic nuclei in the outer layer
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• fewer, shorter cells that appear disorganized
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• reduced numbers and organization of granule neurons at P7
• decreased cholesterol levels and increased levels of sterol intermediates in granule cell precursors at P3, P5, and P7
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• at P7
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• at P7
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• cultured granule cell precursors produce fewer and thinner neurite extensions
• cell morphology is improved with the addition of cholesterol to the culture medium
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• cerebellar Purkinje cells fail to form extensive dendritic trees unlike wild-type controls
• dendritic trees eventually degenerate
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• progressively reduced proliferation of granule cell precursors in cerebella starting at P5
• increase in apoptosis of granule cell precursors in cerebella beginning at P7
• cultured granule cell precurors show reduced proliferation that is largely restored with the addition of cholesterol to the culture medium
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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