cardiovascular system
• increase in cross-sectional area of cardiac myocytes
|
• ventricular/body weight ratio is increased, indicating cardiac hypertrophy
|
• mice exhibit left ventricular hypertrophy as indicated by increased interventricular septal thickness and left ventricular mass
|
• increase in posterior wall thickness
|
• 2-fold increase in interstitial fibrosis
|
muscle
• increase in cross-sectional area of cardiac myocytes
|
• mice exhibit left ventricular hypertrophy as indicated by increased interventricular septal thickness and left ventricular mass
|
growth/size/body
• ventricular/body weight ratio is increased, indicating cardiac hypertrophy
|
• mice exhibit left ventricular hypertrophy as indicated by increased interventricular septal thickness and left ventricular mass
|
cellular
• 2-fold increase in interstitial fibrosis
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
hypertrophic cardiomyopathy 16 | DOID:0110322 |
OMIM:613838 |
J:210073 |