About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Myh6-MYOZ2*S48P)114Ajm
transgene insertion 114, Ali J Marian
MGI:5581488
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Myh6-MYOZ2*S48P)114Ajm/0 involves: FVB MGI:5581490


Genotype
MGI:5581490
tg1
Allelic
Composition
Tg(Myh6-MYOZ2*S48P)114Ajm/0
Genetic
Background
involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• increase in cross-sectional area of cardiac myocytes
• ventricular/body weight ratio is increased, indicating cardiac hypertrophy
• mice exhibit left ventricular hypertrophy as indicated by increased interventricular septal thickness and left ventricular mass
• increase in posterior wall thickness
• 2-fold increase in interstitial fibrosis

muscle
• increase in cross-sectional area of cardiac myocytes
• mice exhibit left ventricular hypertrophy as indicated by increased interventricular septal thickness and left ventricular mass

growth/size/body
• ventricular/body weight ratio is increased, indicating cardiac hypertrophy
• mice exhibit left ventricular hypertrophy as indicated by increased interventricular septal thickness and left ventricular mass

cellular
• 2-fold increase in interstitial fibrosis

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hypertrophic cardiomyopathy 16 DOID:0110322 OMIM:613838
J:210073





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory