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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dnase1l3tm1Dkit
targeted mutation 1, Daisuke Kitamura
MGI:5581508
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dnase1l3tm1Dkit/Dnase1l3tm1Dkit involves: C57BL/6 MGI:5581511


Genotype
MGI:5581511
hm1
Allelic
Composition		 Dnase1l3tm1Dkit/Dnase1l3tm1Dkit
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnase1l3tm1Dkit mutation (2 available); any Dnase1l3 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell death ( J:211019 )
• cultured hepatocytes exhibit impaired necrosis-associated internucleosomal DNA fragmentation (INDF) and lack chromatin condensation compared with wild-type cells
• DNA from liver, kidney, spleen and thymus incubated with saponin in the presence of magnesium and calcium to induce necrosis fail to form DNA ladders unlike DNA from wild-type cells
• following induced liver ischemia, DNA from the liver fails to form DNA ladders unlike DNA from wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory