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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sult1a1tm1Glatt
targeted mutation 1, Hansruedi Glatt
MGI:5581616
Summary 2 genotypes


Genotype
MGI:5581621
hm1
Allelic
Composition		 Sult1a1tm1Glatt/Sult1a1tm1Glatt
Genetic
Background		 FVB.Cg-Sult1a1tm1Glatt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sult1a1tm1Glatt mutation (0 available); any Sult1a1 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
abnormal liver physiology ( J:208180 )
• mice treated with a low dose of methyleugenol fail to produce hepatic DNA adducts unlike in wild-type mice
• mice treated with 1OH-ME produce fewer hepatic DNA adducts by a factor of 120 compared to in wild-type mice
• however, cytochrome P450-mediated metabolism of methyleugenol is normal in the liver

cellular
abnormal cell physiology ( J:217578 )
• mice treated with 1-methylpyrene exhibit decreased benzylic DNA adducts in the liver and kidney compared with wild-type mice that is more severe than in Sult1d1tm1Glatt homozygotes

homeostasis/metabolism
abnormal blood homeostasis ( J:217578 )
• mice treated with 1-methylpyrene exhibit decreased electrophilic 1-sulfooxymethylpyrene plasma levels compared with wild-type mice




Genotype
MGI:5581623
cx2
Allelic
Composition		 Sult1a1tm1Glatt/Sult1a1tm1Glatt
Tg(SULT1A1,SULT1A2)1Glatt/0
Genetic
Background		 FVB.Cg-Sult1a1tm1Glatt Tg(SULT1A1,SULT1A2)1Glatt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sult1a1tm1Glatt mutation (0 available); any Sult1a1 mutation (12 available)
Tg(SULT1A1,SULT1A2)1Glatt mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
abnormal liver physiology ( J:208180 )
• 5-fold increase in the production of hepatic DNA adducts in mice treated with methyleugenol
• 8-fold increase in the levels of hepatic N2-MIE-dG adducts in mice treated with 1OH-ME
• at low doses of methyleugenol, mice exhibit a somewhat supralinear in the dose-relationship for the formation of hepatic DNA adducts compared with wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory