About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(SULT1A1,SULT1A2)1Glatt
transgene insertion 1, Hansruedi Glatt
MGI:5581619
Summary 3 genotypes


Genotype
MGI:5581623
cx1
Allelic
Composition		 Sult1a1tm1Glatt/Sult1a1tm1Glatt
Tg(SULT1A1,SULT1A2)1Glatt/0
Genetic
Background		 FVB.Cg-Sult1a1tm1Glatt Tg(SULT1A1,SULT1A2)1Glatt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sult1a1tm1Glatt mutation (0 available); any Sult1a1 mutation (12 available)
Tg(SULT1A1,SULT1A2)1Glatt mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
abnormal liver physiology ( J:208180 )
• 5-fold increase in the production of hepatic DNA adducts in mice treated with methyleugenol
• 8-fold increase in the levels of hepatic N2-MIE-dG adducts in mice treated with 1OH-ME
• at low doses of methyleugenol, mice exhibit a somewhat supralinear in the dose-relationship for the formation of hepatic DNA adducts compared with wild-type mice




Genotype
MGI:5581622
tg2
Allelic
Composition		 Tg(SULT1A1,SULT1A2)1Glatt/0
Genetic
Background		 FVB-Tg(SULT1A1,SULT1A2)1Glatt
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
abnormal liver physiology ( J:208180 )
• 6-fold increase in the production of hepatic DNA adducts in mice treated with methyleugenol
• 9-fold increase in the levels of hepatic N2-MIE-dG adducts in mice treated with 1OH-ME




Genotype
MGI:5614812
tg3
Allelic
Composition		 Tg(SULT1A1,SULT1A2)1Glatt/0
Genetic
Background		 FVB/N-Tg(SULT1A1,SULT1A2)1Glatt
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell physiology ( J:217578 )
• mice treated with 1-methylpyrene exhibit an increase in benzylic DNA adducts in the liver, lung, heart and kidney, but not colon, compared with wild-type mice

homeostasis/metabolism
abnormal blood homeostasis ( J:217578 )
• mice treated with 1-methylpyrene exhibit increased electrophilic 1-sulfooxymethylpyrene plasma levels compared with wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory