All Phenotypes Myf5<tm2Pas> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Myf5^tm2Pas
targeted mutation 2, Institut Pasteur
MGI:5581636

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myf5^tm2Pas/Myf5^tm2Pas	involves: 129S2/SvPas	MGI:5581657
ht2	Myf5^tm2Pas/Myf5^tm2Tajb	involves: 129S2/SvPas	MGI:3798776
cx3	Lgals1^tm1Rob/Lgals1^tm1Rob Myf5^tm2Pas/Myf5⁺	involves: 129S/SvEv * 129S2/SvPas	MGI:3789015

Allelic Composition	Myf5^tm2Pas/Myf5^tm2Pas
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5^tm2Pas mutation (0 available); any Myf5 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:66277 )

• due to respiratory problems

respiratory system

abnormal respiration ( J:66277 )

• leading to neonatal lethality

skeleton

abnormal rib development ( J:66277 )

Allelic Composition	Myf5^tm2Pas/Myf5^tm2Tajb
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5^tm2Pas mutation (0 available); any Myf5 mutation (17 available)
Myf5^tm2Tajb mutation (0 available); any Myf5 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal muscle regeneration ( J:128921 )

• muscle regeneration is delayed and accompanied by endomysial fibrosis, muscle fiber hypertrophy, increased fiber diameter heterogeneity, and fat accumulation unlike in wild-type mice that is not as severe as in Myf5^tm2Tajb homozygotes

Allelic Composition	Lgals1^tm1Rob/Lgals1^tm1Rob Myf5^tm2Pas/Myf5⁺
Genetic Background	involves: 129S/SvEv * 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgals1^tm1Rob mutation (5 available); any Lgals1 mutation (20 available)
Myf5^tm2Pas mutation (0 available); any Myf5 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

delayed muscle development ( J:119480 )

• mice exhibit a delay in muscle development

• cultured myoblasts exhibit impaired fusion compared to in wild-type myoblasts

abnormal skeletal muscle fiber morphology ( J:119480 )

• myonuclear numbers are decreased

decreased skeletal muscle fiber diameter ( J:119480 )

• adult mice exhibit a 22% reduction in muscle fiber diameter

delayed skeletal muscle regeneration ( J:119480 )

• increase of medium diameter fiber class is delayed after cardiotoxin injury and small tibialis anterior (TA) muscle fibers are prominent up to day 21, whereas large fibers are rarely observed

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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