All Phenotypes Xk<tm1Ariv> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Xk^tm1Ariv
targeted mutation 1, Alicia Rivera
MGI:5581658

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Xk^tm1Ariv/Xk^tm1Ariv	B6.Cg-Xk^tm1Ariv	MGI:5581720
cx2	Kel^tm1Slee/Kel^tm1Slee Xk^tm1Ariv/Y	B6.Cg-Kel^tm1Slee Xk^tm1Ariv	MGI:5581674
cx3	Kel^tm1Slee/Kel^tm1Slee Xk^tm1Ariv/Xk^tm1Ariv	B6.Cg-Kel^tm1Slee Xk^tm1Ariv	MGI:5581719
ot4	Xk^tm1Ariv/Y	B6.Cg-Xk^tm1Ariv	MGI:5581673

Allelic Composition	Xk^tm1Ariv/Xk^tm1Ariv
Genetic Background	B6.Cg-Xk^tm1Ariv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xk^tm1Ariv mutation (0 available); any Xk mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

muscle phenotype ( J:206464 )

N	• no obvious pathology in younger mice

abnormal skeletal muscle fiber morphology ( J:206464 )

• occasional muscle fiber splitting

• occasional angulated atrophic fibers

• occasional diffusely basophilic sarcoplasm

• occasional regenerating muscle fibers in exercising mice

increased variability of skeletal muscle fiber size ( J:206464 )

• variation in muscle fiber size in older mice

centrally nucleated skeletal muscle fibers ( J:206464 )

• frequent internalized nuclei

nervous system

abnormal axon morphology ( J:206464 )

• giant axons found in sciatic nerve and anterior column of spinal cord

• number of giant axons increases in older mice

• giant axons filled with irregularly bundled neurofilaments

• clusters of microtubules, dense lamellar bodies, and membranous structures

abnormal internode morphology ( J:206464 )

• myelin sheaths irregular over internodes of giant axons with extended gaps

decreased myelin sheath thickness ( J:206464 )

• myelin sheaths of giant axons thinner than expected

increased myelin sheath thickness ( J:206464 )

• some small nerve fibers with thicker myelin sheaths than expected

Allelic Composition	Kel^tm1Slee/Kel^tm1Slee Xk^tm1Ariv/Y
Genetic Background	B6.Cg-Kel^tm1Slee Xk^tm1Ariv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kel^tm1Slee mutation (0 available); any Kel mutation (44 available)
Xk^tm1Ariv mutation (0 available); any Xk mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal erythrocyte ion content ( J:212528 )

• 3.2-fold increase in Ca2+ ion content

increased erythrocyte sodium level ( J:212528 )

• small but significant increase

decreased mean corpuscular hemoglobin concentration ( J:212528 )

• slightly decreased

increased mean corpuscular volume ( J:212528 )

• significantly increased

abnormal reticulocyte cell number ( J:212528 )

• modest increase in reticulocyte level (2.71 to 3.6 %)

homeostasis/metabolism

increased erythrocyte sodium level ( J:212528 )

• small but significant increase

Allelic Composition	Kel^tm1Slee/Kel^tm1Slee Xk^tm1Ariv/Xk^tm1Ariv
Genetic Background	B6.Cg-Kel^tm1Slee Xk^tm1Ariv

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon morphology ( J:206464 )

• giant axons found in sciatic nerve and anterior column of spinal cord

• number of giant axons increases in older mice

• giant axons filled with irregularly bundled neurofilaments

• clusters of microtubules, dense lamellar bodies, and membranous structures

abnormal internode morphology ( J:206464 )

• myelin sheaths irregular over internodes of giant axons with extended gaps

decreased myelin sheath thickness ( J:206464 )

• myelin sheaths of giant axons thinner than expected

increased myelin sheath thickness ( J:206464 )

• some small nerve fibers with thicker myelin sheaths than expected

muscle

muscle phenotype ( J:206464 )

N	• no obvious pathology in younger mice

abnormal skeletal muscle fiber morphology ( J:206464 )

• occasional muscle fiber splitting

• occasional angulated atrophic fibers

• occasional diffusely basophilic sarcoplasm

increased variability of skeletal muscle fiber size ( J:206464 )

• variation in muscle fiber size in older mice

centrally nucleated skeletal muscle fibers ( J:206464 )

• frequent internalized nuclei

Allelic Composition	Xk^tm1Ariv/Y
Genetic Background	B6.Cg-Xk^tm1Ariv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xk^tm1Ariv mutation (0 available); any Xk mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal erythrocyte ion content ( J:212528 )

• 2.7-fold increase in Ca2+ ion content

increased erythrocyte magnesium level ( J:212528 )

increased mean corpuscular hemoglobin concentration ( J:212528 )

• small but significant increase

homeostasis/metabolism

increased erythrocyte magnesium level ( J:212528 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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