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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mafbtm1.1Good
targeted mutation 1.1, Lisa Goodrich
MGI:5581666
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mafbtm1.1Good/Mafbtm1.1Good involves: 129S4/SvJae * C57BL/6 * SJL MGI:5581684
cn2
 		Mafbtm1.1Good/Mafbtm1Jeng
Foxg1tm1(cre)Skm/Foxg1+ 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL MGI:5581686
cn3
 		Mafbtm1.1Good/Mafbtm1Jeng
Tg(Neurog1-cre)1Jejo/0 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL MGI:5581687


Genotype
MGI:5581684
hm1
Allelic
Composition		 Mafbtm1.1Good/Mafbtm1.1Good
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mafbtm1.1Good mutation (0 available); any Mafb mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:207904 )
• mice are fertile and viable with normal hearing and no gross anatomical defects




Genotype
MGI:5581686
cn2
Allelic
Composition		 Mafbtm1.1Good/Mafbtm1Jeng
Foxg1tm1(cre)Skm/Foxg1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (29 available)
Mafbtm1.1Good mutation (0 available); any Mafb mutation (20 available)
Mafbtm1Jeng mutation (0 available); any Mafb mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

respiratory system
apnea ( J:207904 )
• central apnea

hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:207904 )
N
• inner ear develops normally

nervous system
nervous system phenotype ( J:207904 )
N
• spiral ganglion neuron neurite organization is normal




Genotype
MGI:5581687
cn3
Allelic
Composition		 Mafbtm1.1Good/Mafbtm1Jeng
Tg(Neurog1-cre)1Jejo/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mafbtm1.1Good mutation (0 available); any Mafb mutation (20 available)
Mafbtm1Jeng mutation (0 available); any Mafb mutation (20 available)
Tg(Neurog1-cre)1Jejo mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:207904 )
N
• mice survive through adulthood

nervous system
nervous system phenotype ( J:207904 )
N
• spiral ganglion neuron (SGN) processes organization and density are normal
• efferent innervation of cochlea is normal
• SGN firing properties are normal
abnormal inner hair cell synaptic ribbon morphology ( J:207904 )
• some are abnormally small or misshapen
• reduced numbers at P15
abnormal cochlear ganglion morphology ( J:207904 )
• failure of post-synpatic differentiation near the basolateral pole of the inner hair cells by P6
• impaired presynaptic development

hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:207904 )
N
• distortion product otoacoustic emissions are normal
abnormal inner hair cell synaptic ribbon morphology ( J:207904 )
• some are abnormally small or misshapen
• reduced numbers at P15
increased or absent threshold for auditory brainstem response ( J:207904 )
• dampened auditory brainstem response (ABR) waveforms and elevated auditory thresholds
• ABR wave I is delayed with increased latency compared to in control mice




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory