normal phenotype
• mice are fertile and viable with normal hearing and no gross anatomical defects
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Allele Symbol Allele Name Allele ID |
Mafbtm1.1Good targeted mutation 1.1, Lisa Goodrich MGI:5581666 |
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Summary |
3 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice are fertile and viable with normal hearing and no gross anatomical defects
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|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• inner ear develops normally
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N |
• spiral ganglion neuron neurite organization is normal
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|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• mice survive through adulthood
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N |
• spiral ganglion neuron (SGN) processes organization and density are normal
• efferent innervation of cochlea is normal
• SGN firing properties are normal
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• some are abnormally small or misshapen
• reduced numbers at P15
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• failure of post-synpatic differentiation near the basolateral pole of the inner hair cells by P6
• impaired presynaptic development
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N |
• distortion product otoacoustic emissions are normal
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• some are abnormally small or misshapen
• reduced numbers at P15
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• dampened auditory brainstem response (ABR) waveforms and elevated auditory thresholds
• ABR wave I is delayed with increased latency compared to in control mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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