Phenotypes associated with this allele

• Allele Symbol: Rcor1^tm2.2Gman
• Allele Name: targeted mutation 2.2, Gail Mandel
• Allele ID: MGI:5581675
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rcor1^tm2.2Gman/Rcor1^tm2.2Gman	B6.129S1(SJL)-Rcor1^tm2.2Gman	MGI:5581677

Genotype
MGI:5581677

hm1

• Allelic Composition: Rcor1^tm2.2Gman/Rcor1^tm2.2Gman
• Genetic Background: B6.129S1(SJL)-Rcor1^tm2.2Gman

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal embryonic erythropoiesis ( J:211681 )

• fetal livers primarily contain early erythroblasts

• most E14.5 fetal liver cells are arrested at the proerythroblast stage (R2 to R3) rather than progressing to R3 and R4

• blood from E15.5 embryos lacks mature, enucleated RBCs as compared to the presence of 90% enucleated RBCs in controls

hematopoietic system

abnormal embryonic erythropoiesis ( J:211681 )

• fetal livers primarily contain early erythroblasts

• most E14.5 fetal liver cells are arrested at the proerythroblast stage (R2 to R3) rather than progressing to R3 and R4

• blood from E15.5 embryos lacks mature, enucleated RBCs as compared to the presence of 90% enucleated RBCs in controls

decreased erythroid progenitor cell number ( J:211681 )

• very few if any CFU-E colonies are detected in proerythroblast (R2) stage cells from E13.5 liver cells

mortality/aging

postnatal lethality, complete penetrance ( J:211681 )

• no homozygotes survive to P7

embryonic lethality, incomplete penetrance ( J:211681 )

• although present at the expected Mendelian ratios at E13.5, ~75% of mutant embryos are dead by E16.5