All Phenotypes Ncoa5<tm1Hxia> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ncoa5^tm1Hxia/Ncoa5⁺	C.129(B6)-Ncoa5^tm1Hxia	MGI:5581718
ht2	Ncoa5^tm1Hxia/Ncoa5⁺	involves: 129 * C57BL/6	MGI:5581714
cx3	Il6^tm1Kopf/Il6⁺ Ncoa5^tm1Hxia/Ncoa5⁺	involves: 129 * 129S2/SvPas * C57BL/6	MGI:7294376
cx4	Il6^tm1Kopf/Il6⁺ Ncoa5^tm1Hxia/Ncoa5⁺	involves: 129S2/SvPas * BALB/c * C57BL/6	MGI:5581716
cx5	Il6^tm1Kopf/Il6⁺ Ncoa5^tm1Hxia/Ncoa5^tm1Hxia	involves: 129S2/SvPas * C57BL/6	MGI:5581717
cx6	Il6^tm1Kopf/Il6⁺ Ncoa5^tm1Hxia/Ncoa5⁺	involves: 129S2/SvPas * C57BL/6	MGI:5581715

Allelic Composition	Ncoa5^tm1Hxia/Ncoa5⁺
Genetic Background	C.129(B6)-Ncoa5^tm1Hxia

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncoa5^tm1Hxia mutation (0 available); any Ncoa5 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased fasting circulating glucose level ( J:207622 )

• at 20 weeks in male, but not female, mice

impaired glucose tolerance ( J:207622 )

• at 20 weeks in male, but not female, mice

neoplasm

increased hepatocellular carcinoma incidence ( J:207622 )

• at 10 to 18 months, most male mice develop spontaneous liver tumors (well to moderately differentiated HCC) with occasional lung metastasis unlike female or wild-type mice

liver/biliary system

increased hepatocellular carcinoma incidence ( J:207622 )

• at 10 to 18 months, most male mice develop spontaneous liver tumors (well to moderately differentiated HCC) with occasional lung metastasis unlike female or wild-type mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:207622 )

N	• female mice are fertile

teratozoospermia ( J:284227 )

• at 4 months of age, a significant proportion of cauda epididymal spermatozoa appear morphologically abnormal

• abnormal sperm morphology appears during transit from the head to the tail of the epididymis

• however, the morphology of sperm collected from testis is normal

abnormal sperm midpiece morphology ( J:284227 )

• TEM analysis of cauda epididymal sperm showed that the midpiece consists of disrupted mitochondria and axoneme wrapped around the bent head and neck

abnormal sperm mitochondrial morphology ( J:284227 )

• disrupted mitochondria are observed in the midpiece

abnormal sperm head morphology ( J:284227 )

• phase contrast images revealed many cauda epididymal sperm with misshapen heads

• SEM showed that some cauda epididymal sperm heads have a roughly uneven surface and bend over with the tip of the head toward the tail or curl like a golf stick; other sperm curl as a disk-like structure by wrapping around the head with the neck and middle parts of the tail

decreased sperm progressive motility ( J:284227 )

• at 4 months of age, the % of progressively motile sperm is significantly lower than that in wild-type males

asthenozoospermia ( J:284227 )

• at 4 months of age, the % of motile cauda epididymal sperm is significantly lower than that in wild-type males

• however, cauda epididymal sperm concentration is relatively normal

male infertility ( J:207622 , J:284227 )

(J:207622)

• when bred with female heterozygotes over a period of 6 months, most male heterozygotes (26/30) at ages of 2-8 months are unable to father a litter (J:284227)

reduced male fertility ( J:284227 )

• when bred with female heterozygotes over a period of 6 months, only ~13% of male heterozygotes (4/30) are able to father a litter with 2-4 pups per litter at earlier ages

• even when bred with wild-type females, only ~30% of male heterozygotes (3/10) are capable of fathering a litter, indicating severely impaired male fertility

abnormal epididymis physiology ( J:284227 )

• at 13-15 months of age, expression of interleukin-6 (IL-6) is significantly increased in the epididymis relative to that in age-matched wild-type males

• at 4.5 months of age, IHC staining showed a significantly higher IL-6 expression in the epithelial cells of the caput, corpus and cauda of the epididymis than in wild-type epididymis

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:207622 )

N	• mice exhibit normal serum insulin, triglyceride and free fatty acid levels

increased fasting circulating glucose level ( J:207622 )

• at 6 weeks in male, but not female, mice

abnormal circulating protein level ( J:207622 )

• increased circulating alpha-fetal protein at 6 and 12 months in male mice

• however, levels are normal at 2 months

increased circulating alanine transaminase level ( J:207622 )

• at 6 and 12 months in male mice

impaired glucose tolerance ( J:207622 )

• early-onset at 6 weeks in male, but not female, mice

insulin resistance ( J:207622 )

• at 6 weeks in male, but not female, mice

increased liver triglyceride level ( J:207622 )

• in male, but not female, mice at 10 months

• however, levels at 6 month are normal

liver/biliary system

increased hepatocyte apoptosis ( J:207622 )

• in male mice

increased hepatocyte proliferation ( J:207622 )

• in male mice

chronic liver inflammation ( J:207622 )

• chronic in male, but not female, mice with immune cell infiltrations around the bile ducts and in the portal areas, focal aggregates of lymphocytes, neutrophils and macrophage

abnormal liver morphology ( J:207622 )

• at 6 or 10 months, male mice exhibit dysplasia with disorganized architecture, cytological atypia, enlarged nuclei and vacuolated hepatocytes compare with wild-type and female mice

increased liver triglyceride level ( J:207622 )

• in male, but not female, mice at 10 months

• however, levels at 6 month are normal

hepatic steatosis ( J:207622 )

• in male, but not female, mice at 6 or 10 months

increased hepatocellular carcinoma incidence ( J:207622 )

• at 10 to 18 months, nearly all male mice develop spontaneous liver tumors (well to moderately differentiated HCC) with occasional lung metastasis unlike female or wild-type mice

liver fibrosis ( J:207622 )

• in the periportal and periductular areas of male mice at 10 months

neoplasm

increased hepatocellular carcinoma incidence ( J:207622 )

• at 10 to 18 months, nearly all male mice develop spontaneous liver tumors (well to moderately differentiated HCC) with occasional lung metastasis unlike female or wild-type mice

immune system

chronic liver inflammation ( J:207622 )

• chronic in male, but not female, mice with immune cell infiltrations around the bile ducts and in the portal areas, focal aggregates of lymphocytes, neutrophils and macrophage

cellular

teratozoospermia ( J:284227 )

• at 4 months of age, a significant proportion of cauda epididymal spermatozoa appear morphologically abnormal

• abnormal sperm morphology appears during transit from the head to the tail of the epididymis

• however, the morphology of sperm collected from testis is normal

abnormal sperm midpiece morphology ( J:284227 )

• TEM analysis of cauda epididymal sperm showed that the midpiece consists of disrupted mitochondria and axoneme wrapped around the bent head and neck

abnormal sperm mitochondrial morphology ( J:284227 )

• disrupted mitochondria are observed in the midpiece

abnormal sperm head morphology ( J:284227 )

• phase contrast images revealed many cauda epididymal sperm with misshapen heads

increased hepatocyte apoptosis ( J:207622 )

• in male mice

decreased sperm progressive motility ( J:284227 )

• at 4 months of age, the % of progressively motile sperm is significantly lower than that in wild-type males

asthenozoospermia ( J:284227 )

• at 4 months of age, the % of motile cauda epididymal sperm is significantly lower than that in wild-type males

• however, cauda epididymal sperm concentration is relatively normal

increased hepatocyte proliferation ( J:207622 )

• in male mice

endocrine/exocrine glands

decreased pancreatic islet number ( J:207622 )

• in male mice at 8 and 24 weeks

small pancreatic islets ( J:207622 )

• decreased mass in male mice at 8 and 24 weeks

Allelic Composition	Il6^tm1Kopf/Il6⁺ Ncoa5^tm1Hxia/Ncoa5⁺
Genetic Background	involves: 129 * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6^tm1Kopf mutation (9 available); any Il6 mutation (38 available)
Ncoa5^tm1Hxia mutation (0 available); any Ncoa5 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

teratozoospermia ( J:284227 )

• SEM and TEM analyses of cauda epididymal sperm showed significantly improved sperm ultrastructure relative to single Ncoa5^tm1Hxia male heterozygotes

increased sperm motility ( J:284227 )

• at 4 months of age, the % of motile cauda epididymal sperm is significantly higher than that in single Ncoa5^tm1Hxia male heterozygotes

increased sperm progressive motility ( J:284227 )

• at 4 months of age, the % of progressively motile sperm is significantly higher than that in single Ncoa5^tm1Hxia male heterozygotes

enhanced male fertility ( J:284227 )

• when bred with double heterozygous females, 5 out of 6 double heterozygous males are able to father litters with 2 to 8 pups per litter, in contrast to single Ncoa5^tm1Hxia male heterozygotes

abnormal epididymis physiology ( J:284227 )

• at 4.5 months of age, IHC staining showed that epididymal expression of IL-6 is markedly lower than that in single Ncoa5^tm1Hxia male heterozygotes

cellular

teratozoospermia ( J:284227 )

• SEM and TEM analyses of cauda epididymal sperm showed significantly improved sperm ultrastructure relative to single Ncoa5^tm1Hxia male heterozygotes

increased sperm motility ( J:284227 )

• at 4 months of age, the % of motile cauda epididymal sperm is significantly higher than that in single Ncoa5^tm1Hxia male heterozygotes

increased sperm progressive motility ( J:284227 )

• at 4 months of age, the % of progressively motile sperm is significantly higher than that in single Ncoa5^tm1Hxia male heterozygotes

Allelic Composition	Il6^tm1Kopf/Il6⁺ Ncoa5^tm1Hxia/Ncoa5⁺
Genetic Background	involves: 129S2/SvPas * BALB/c * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:207622 )

N	• unlike Ncoa5^tm1Hxia male heterozygotes, male mice exhibit normal circulating glucose levels and improved glucose tolerance

Allelic Composition	Il6^tm1Kopf/Il6⁺ Ncoa5^tm1Hxia/Ncoa5^tm1Hxia
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:207622 )

• no mice are produced from fertile double heterozygotes

Allelic Composition	Il6^tm1Kopf/Il6⁺ Ncoa5^tm1Hxia/Ncoa5⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

increased hepatocellular carcinoma incidence ( J:207622 )

• fewer and smaller maximum tumor volume than in Ncoa5^tm1Hxia male heterozygotes

reproductive system

reproductive system phenotype ( J:207622 )

N	• unlike Ncoa5^tm1Hxia male heterozygotes, male mice are fertile

neoplasm

increased hepatocellular carcinoma incidence ( J:207622 )

• fewer and smaller maximum tumor volume than in Ncoa5^tm1Hxia male heterozygotes

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:207622 )

N	• unlike Ncoa5^tm1Hxia male heterozygotes, male mice exhibit normal circulating glucose levels, glucose tolerance and insulin sensitivity

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