homeostasis/metabolism
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• at 20 weeks in male, but not female, mice
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• at 20 weeks in male, but not female, mice
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neoplasm
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• at 10 to 18 months, most male mice develop spontaneous liver tumors (well to moderately differentiated HCC) with occasional lung metastasis unlike female or wild-type mice
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liver/biliary system
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• at 10 to 18 months, most male mice develop spontaneous liver tumors (well to moderately differentiated HCC) with occasional lung metastasis unlike female or wild-type mice
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