Phenotypes associated with this allele

• Allele Symbol: Myh11^tm1.1Dmmz
• Allele Name: targeted mutation 1.1, Dianna M Milewicz
• Allele ID: MGI:5582321
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myh11^tm1.1Dmmz/Myh11^tm1.1Dmmz	involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6	MGI:5582322

Genotype
MGI:5582322

hm1

• Allelic Composition: Myh11^tm1.1Dmmz/Myh11^tm1.1Dmmz
• Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:212664 )

N • mice exhibit normal aorta morphology and blood pressure

abnormal vascular smooth muscle physiology ( J:212664 )

• aortic smooth muscle cell explants exhibit reduced focal adhesion compared with wild-type cells

increased vascular smooth muscle cell proliferation ( J:212664 )

• following carotid artery ligation, mice exhibit excessive smooth muscle cell proliferation compared with wild-type mice

• aortic smooth muscle cell explants exhibit increased cell proliferation compared with wild-type cells

decreased vasoconstriction ( J:212664 )

• in response to phenylephrine of KCl, aortic rings exhibit attenuated contractile force development compared with wild-type mice

abnormal vascular wound healing ( J:212664 )

• following carotid artery ligation, mice exhibit enhanced neointima formation compared with wild-type mice with increased neointimal area, intima to media ratio, medial area and smooth muscle cell proliferation

cellular

increased vascular smooth muscle cell proliferation ( J:212664 )

• following carotid artery ligation, mice exhibit excessive smooth muscle cell proliferation compared with wild-type mice

• aortic smooth muscle cell explants exhibit increased cell proliferation compared with wild-type cells

abnormal cell adhesion ( J:212664 )

• aortic smooth muscle cell explants exhibit reduced focal adhesion compared with wild-type cells

homeostasis/metabolism

abnormal vascular wound healing ( J:212664 )

• following carotid artery ligation, mice exhibit enhanced neointima formation compared with wild-type mice with increased neointimal area, intima to media ratio, medial area and smooth muscle cell proliferation

muscle

abnormal vascular smooth muscle physiology ( J:212664 )

• aortic smooth muscle cell explants exhibit reduced focal adhesion compared with wild-type cells

increased vascular smooth muscle cell proliferation ( J:212664 )

• following carotid artery ligation, mice exhibit excessive smooth muscle cell proliferation compared with wild-type mice

• aortic smooth muscle cell explants exhibit increased cell proliferation compared with wild-type cells

decreased vasoconstriction ( J:212664 )

• in response to phenylephrine of KCl, aortic rings exhibit attenuated contractile force development compared with wild-type mice