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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il22ra1tm1Rsab
targeted mutation 1, Robert Sabat
MGI:5582472
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ikbkbtm1Cgn/Ikbkbtm1Cgn
Il22ra1tm1Rsab/Il22ra1tm1Rsab
Tg(KRT14-cre)1Cgn/0 		involves: C57BL/6 * DBA/2 MGI:5582486


Genotype
MGI:5582486
cn1
Allelic
Composition		 Ikbkbtm1Cgn/Ikbkbtm1Cgn
Il22ra1tm1Rsab/Il22ra1tm1Rsab
Tg(KRT14-cre)1Cgn/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkbtm1Cgn mutation (0 available); any Ikbkb mutation (56 available)
Il22ra1tm1Rsab mutation (0 available); any Il22ra1 mutation (31 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:208995 )
N
• mice survive to adulthood

integument
skin inflammation ( J:208995 )
• delayed onset and decelerated development compared with Ikbkbtm1Cgn/Ikbkbtm1Cgn Tg(KRT14-cre)1Cgn
• mild inflammation at 7 weeks
• cutaneous inflammation of variable degree on the abdomen, flanks and throat at 14 weeks
epidermal hyperplasia ( J:208995 )
• at P8, milder than in Ikbkbtm1Cgn/Ikbkbtm1Cgn Tg(KRT14-cre)1Cgn
skin lesions ( J:208995 )
• delayed onset and decelerated development compared with Ikbkbtm1Cgn/Ikbkbtm1Cgn Tg(KRT14-cre)1Cgn

immune system
skin inflammation ( J:208995 )
• delayed onset and decelerated development compared with Ikbkbtm1Cgn/Ikbkbtm1Cgn Tg(KRT14-cre)1Cgn
• mild inflammation at 7 weeks
• cutaneous inflammation of variable degree on the abdomen, flanks and throat at 14 weeks




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory